Electrochemical Synergistic Ni/Co-Catalyzed Carbonylative Cross-Electrophile Coupling of Aryl and Alkyl Halides with CO

JACS Au, Год журнала: 2025, Номер 5(3), С. 1413 - 1420

Опубликована: Март 5, 2025

Accessing unsymmetric ketones and achieving their carbon isotope labeling are crucial yet challenging tasks in both synthetic medicinal chemistry. We report here an efficient electrochemical nickel-/cobalt-catalyzed carbonylative cross-electrophile coupling reaction. This method allows for the modular synthesis of a library from simple building blocks, including aryl halides, alkyl gaseous CO. The simultaneous use nickel cobalt salts as concerted catalysts ensures high efficiency this three-component coupling. Furthermore, reduction avoids stoichiometric reductants, making protocol more sustainable attractive. broad substrate scope late-stage 13C complex molecules derived biologically active compounds highlight practicality method.

Язык: Английский

Turning Alkyl Iodides into Acyl Fluorides by Photoinduced Copper-Catalyzed Fluorocarbonylation

Synfacts, Год журнала: 2024, Номер 20(07), С. 0726 - 0726

Опубликована: Июнь 14, 2024

Key words acyl fluorides - alkyl iodides carbon monoxide carbonylative coupling copper catalysis fluorocarbonylation

Язык: Английский