Visible-Light-Driven Synthesis of N-Alkyl α-Amino Acid Derivatives from Unactivated Alkyl Bromides and In Situ Generated Imines DOI
Sen Yang,

Chaoying Qiu,

Hao Hu

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

One-pot, multicomponent reactions are known for their green and efficient nature. We report a novel three-component reaction of alkyl amines, glyoxylates, unactivated bromides under visible-light-induced palladium catalysis, yielding

Язык: Английский

Photoinduced Pd-Catalyzed Formal Asymmetric Allylic Substitution of Piperidine Scaffolds DOI

Weidong Lu,

Zhilin Liu,

Zi‐Hao Liao

и другие.

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 4384 - 4393

Опубликована: Фев. 26, 2025

Язык: Английский

Процитировано

1
Visible-light-mediated synthesis of polysubstituted pyrroles via CAr–I reduction triggered 1,5-hydrogen atom transfer process DOI
Junlei Wang,

Qinglin Xie,

Guocheng Gao

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(16), С. 4522 - 4528

Опубликована: Янв. 1, 2024

A novel strategy for the construction of polysubstituted pyrroles has been developed through visible-light-induced single-electron reduction C Ar –I bonds and following 1,5-hydrogen atom transfer (HAT) process.

Язык: Английский

Процитировано

6
Transition‐Metal‐Free Radical Relay Cascade Annulation of Amides: Access to Antitumor Active Benzo[b]azepine and Oxindole Derivatives DOI

Xia-xin Sheng,

Chao-ying Qiu,

Lina Wang

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер 30(63)

Опубликована: Авг. 26, 2024

Abstract Efficient transition‐metal‐free synthesis of benzo[b]azepines and oxindoles is achieved via a radical relay cascade strategy employing halogen atom transfer (XAT) for aryl generation followed by intramolecular hydrogen (HAT). Optimization yielded moderate to substantial yields under visible light irradiation. Preliminary biological assessments revealed promising anti‐tumor activity select compounds. This study underscores the potential XAT‐mediated cascades in medicinal chemistry anticancer drug discovery.

Язык: Английский

Процитировано

2
Divergent Synthesis of (E)- and (Z)-Alkenones via Photoredox C(sp3)–H Alkenylation–Dehydrogenation of o-Iodoarylalkanols with Alkynes DOI

Liang Zeng,

Yin Zhang,

Ming Hu

и другие.

Organic Letters, Год журнала: 2024, Номер 26(47), С. 10096 - 10101

Опубликована: Ноя. 15, 2024

A photoredox C(sp3)–H alkenylation–dehydrogenation of o-iodoarylalkanols with terminal alkynes for the synthesis (E)- and (Z)-quaternary carbon center-containing pent-4-en-1-ones is described. The stereoselectivity depends on utilization photocatalysts. While using an organic photocatalyst like 4-DPAIPN manipulates arylalkynes to assemble (E)-pent-4-en-1-ones, in case Ir potocatalyst such as Ir(ppy)2(dtbbpy)PF6 reaction delivers (Z)-pent-4-en-1-ones. For alkylalkynes, furnishes (E)-pent-4-en-1-ones exclusively presence or Ir(ppy)2(dtbbpy)PF6.

Язык: Английский

Процитировано

1
Visible-Light-Driven Synthesis of N-Alkyl α-Amino Acid Derivatives from Unactivated Alkyl Bromides and In Situ Generated Imines DOI
Sen Yang,

Chaoying Qiu,

Hao Hu

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

One-pot, multicomponent reactions are known for their green and efficient nature. We report a novel three-component reaction of alkyl amines, glyoxylates, unactivated bromides under visible-light-induced palladium catalysis, yielding

Язык: Английский

Процитировано

0