New Journal of Chemistry, Год журнала: 2024, Номер 48(47), С. 19746 - 19749
Опубликована: Янв. 1, 2024
A gentle and remarkably effective copper-catalyzed method for the cascade sulfonylation of alkynes using sulfonyl chlordies as direct sulfonylating reagents, is presented.
Язык: Английский
Beilstein Journal of Organic Chemistry, Год журнала: 2025, Номер 21, С. 55 - 121
Опубликована: Янв. 9, 2025
Axial chirality is present in a variety of naturally occurring compounds, and becoming increasingly relevant also medicine. Many axially chiral compounds are important as catalysts asymmetric catalysis or have chiroptical properties. This review overviews recent progress the synthesis via organocatalysis. Atroposelective organocatalytic reactions discussed according to dominant catalyst activation mode. For covalent organocatalysis, typical enamine iminium modes presented, followed by N -heterocyclic carbene-catalyzed reactions. The bulk devoted non-covalent activation, where Brønsted acids feature most prolific catalytic structure. last part article discusses hydrogen-bond-donating other motifs such phase-transfer catalysts.
Язык: Английский
Процитировано
1
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Sulfone motifs play important roles in bioactive compounds and functional materials. The development of efficient methodologies for constructing sulfonyl-containing has thus attracted considerable attention. Here, we introduce a protocol the preparation alkyl aryl sulfones under mild conditions. This employs β-thioamide sulfone as novel motif donor. It forms sulfinates situ basic conditions, which then undergo cross-coupling with intermediates that were generated from ligand-free copper-catalyzed cyclopropenes (CPEs) ring opening.
Язык: Английский
Процитировано
0
Tetrahedron, Год журнала: 2025, Номер unknown, С. 134726 - 134726
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
In this article, the synthesis of γ-keto sulfones over period from 2020 to present will be discussed, and related reaction mechanisms also discussed.
Язык: Английский
Процитировано
0
Chinese Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Comprehensive Summary Alkenylsulfonates are commonly encountered in medicinal chemistry, polymer and organic synthesis. In this research, an electrochemical reaction involving alkynes, NaHSO 3 , alcohols has been developed. This method yields functionalized alkenylsulfonates good with broad functional group tolerance. Mechanism studies indicate that anodic oxidation of inorganic sulfite, radical insertion process, HAT process involved transformation.
Язык: Английский
Процитировано
2
The Journal of Organic Chemistry, Год журнала: 2024, Номер 90(1), С. 908 - 912
Опубликована: Дек. 31, 2024
A three-component reaction of alkenyl thianthrenium salts, cyclopropan-1-ols and DABCO·(SO2)2 under catalyst- additive-free conditions, is accomplished. This sulfonylation with the insertion sulfur dioxide works efficiently very mild leading to a wide range 1-substituted vinyl sulfones in moderate good yields. In this protocol, scope generality salts cyclopropyl alcohols demonstrated.
Язык: Английский
Процитировано
2
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16873 - 16882
Опубликована: Ноя. 6, 2024
Isoindolones constitute a dominant structural class in synthetic and medicinal chemistry. In this research, an electrochemical reaction involving 2-alkynylbenzamides, inorganic sulfites, alcohols was first established to provide sulfonyl ester-substituted 3-hydroxyisoindolinone derivatives moderate good yields with excellent functional group tolerance. When bulky aryl-substituted 2-alkynylbenzamides are utilized as substrates, 3-alkylideneisoindolinones can be selectively generated chemoselectivity. Alkoxysulfonyl radicals derived from the anodic oxidation of sulfite involved transformation.
Язык: Английский
Процитировано
1
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
The review summarizes achievements in stereoselective and stereoretentive transformations of cyclopropanols suitable for asymmetric synthesis.
Язык: Английский
Процитировано
1
Chemistry - A European Journal, Год журнала: 2024, Номер 30(49)
Опубликована: Июнь 26, 2024
Vinylidene ortho-quinone methides (VQMs) have been proven to be versatile and crucial intermediates in the catalytic asymmetric reaction last decade, thus drawn considerable concentrations on account of practical application construction enantiomerically pure functional organic molecules. However, comparison well established chiral Brønsted base-catalyzed via VQMs, acid-catalyzed is rarely studied there no systematic summary date. In this review, we summarize recent advances VQMs according three types reactions: a) intermolecular nucleophilic addition VQMs; b) cycloaddition c) intramolecular cyclization VQMs. Finally, put forward remained challenges opportunities for potential breakthroughs area.
Язык: Английский
Процитировано
0
New Journal of Chemistry, Год журнала: 2024, Номер 48(47), С. 19746 - 19749
Опубликована: Янв. 1, 2024
A gentle and remarkably effective copper-catalyzed method for the cascade sulfonylation of alkynes using sulfonyl chlordies as direct sulfonylating reagents, is presented.
Язык: Английский
Процитировано
0