Recent Progress in Visible Light‐Mediated Synthesis of γ‐lactams
Helvetica Chimica Acta,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Abstract
The
integration
of
sustainable
practices,
such
as
employing
renewable
light
sources
for
synthesizing
valuable
synthetic
scaffolds,
has
been
progressing
over
the
past
few
decades.
Among
these
noteworthy
organic
frameworks,
lactams,
particularly
γ‐lactams,
have
established
their
prominence
due
to
extensive
applications
in
pharmaceutical,
agricultural,
and
medicinal
domains.
This
growing
significance
γ‐lactams
spurred
considerable
interest
synthesis,
especially
via
milder,
more
sustainable,
environmentally
friendly
methods.
In
recent
years,
numerous
innovative
reaction
mechanisms
explored,
highlighting
how
photocatalysis
can
enable
formation
from
readily
accessible
precursors
through
C−N
bond
cyclization
processes.
review
emphasizes
potential
photocatalytic
strategies
not
only
enhance
current
methods
but
also
foster
development
greener
chemical
processes
future.
Язык: Английский
Silver- and Base-Enabled SOMOphilic Alkynylation of Alkylboronic Acids with Bromoalkynes
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
Alkynyl-containing
molecules
hold
significant
importance
in
organic
synthesis,
drug
discovery,
and
materials
science.
Herein,
we
report
an
efficient
protocol
for
the
C(sp)-C(sp3)
cross-coupling
of
bromoalkynes
with
primary,
secondary,
tertiary
alkylboronic
acids.
Mechanistic
experiments
suggest
that
silver
base
enable
generation
alkyl
radical
intermediate
from
acid
then
undergo
a
cascade
α-addition
β-elimination
alkynyl
bromides,
leading
to
construction
bonds.
This
strategy
features
readily
available
starting
materials,
diverse
substrates,
mild
easily
handled
reaction
conditions.
Язык: Английский