Organic Letters,
Год журнала:
2024,
Номер
26(49), С. 10548 - 10552
Опубликована: Ноя. 28, 2024
A
Pd/norbornene-mediated
three-component
modular
one-step
reaction
facilitated
by
dual
C-H
bond
activation
and
cascade
cyclization
is
reported.
This
procedure
uses
norbornene
as
a
catalyst
in
the
Catellani-type
an
alkylating
building
block
to
accomplish
unactivated
functionalization
protocol,
which
results
production
of
polyheterocyclic
eight-membered
sulfoximines
with
indene-fused
moiety.
mild,
scalable
protocol's
wide
substrate
range
makes
it
ideal
for
site-selective
at
highly
chemoselective
aryl
sites.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
A
novel
visible-light-induced
sulfonylation
cyclization
to
indole-fused
medium-sized
N-heterocycles
was
established
under
room
temperature
with
biomass-derived
2-Me-THF
as
the
solvent.
This
reaction
proceeds
in
absence
of
external
photocatalyst,
additive,
metal
salts,
and
base.
Broad
substrate
scope,
good
functional
group
compatibility,
large-scale
synthesis
derivatization
via
iodination,
nitration,
chlorination,
cyanation,
selenylation
demonstrate
utility
this
protocol.
radical
route
proposed
based
on
inhibition
experiments,
visible-light
irradiation
on-off
test,
apparent
quantum
efficiency
calculation,
UV-vis
absorption
spectroscopic
studies.
A
mild
and
atom-economical
reaction
for
the
Sc(OTf)3-catalyzed
1,3-hydroxyheteroarylation
of
bicyclo[1.1.0]butanes
(BCBs)
with
azaaryl
N-oxides
via
an
unprecedented
[4π+2σ]
cycloaddition/ring-opening
process
is
described.
This
transformation
provides
a
novel
strategy
highly
regio-
diastereoselective
preparation
azaheterocycle-tethered
1,1,3,3-tetrasubstituted
cyclobutane
derivatives
offers
broad
substrate
scope
high
yields.
A
ligand-modulated
synergetic
nickel/photoredox-catalyzed
exo-arylalkylation
of
unactivated
alkynes
was
developed
that
strikingly
different
from
the
known
endo-arylalkylation
activated
arylacetylenes.
The
unique
arylalkylation
pathway
due
to
formation
a
π-allyl-Ni
complex
alkyne
where
nickel
species
engaged
in
distinctive
dual-catalytic
cycle.
exo-alkenylation
applied
divergent
synthesis
tryptamines
and
benzofurylethylamines.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(19), С. 5564 - 5572
Опубликована: Янв. 1, 2024
This
study
reports
the
electrochemical
reaction
of
vinylcyclopropanes
with
sulfonyl
chlorides,
resulting
in
1,5-hydrosulfonylation
and
1,5-chlorosulfonylation.
Nitrogen
central
radicals
(NCRs)
are
versatile
synthetic
intermediates
for
creating
functional
nitrogen-containing
molecules.
Herein,
a
photosensitized
β-sulfonylamination
of
terminal
alkynes
as
well
acetylene
has
been
established
by
employing
N-sulfonyl
heteroaromatics
bifunctional
reagents
(BFRs)
to
efficiently
deliver
(E)-β-sulfonylvinylamines
with
excellent
regio-
and
stereoselectivities.
Mechanistic
studies
suggest
base-accelerated
energy
transfer
(EnT)
photocatalysis
involving
aromatic
NCR
formation,
radical
addition
alkynes,
sulfonylation
processes.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
We
report
an
electrophotocatalytic
process
that
enables
the
thiocyanation
and
sulfonylation/cyclization
of
alkenes.
It
is
applicable
to
a
wide
range
unactivated
alkenes,
using
inexpensive
photocatalyst
2,4,6-triphenylpyrylium
tetrafluoroborate
(TPPT)
produce
diverse
array
heterocycles
containing
sulfonyl
thiocyano
groups
with
good
functional
group
tolerance.
The
protocol
operates
under
mild,
chemical
oxidant-
transition-metal-free,
broad
scope
substrates.
Preliminary
mechanistic
studies
suggest
reaction
involves
combination
electrolysis
reductive
quenching
photocatalytic
cycle
TPPT.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(31), С. 6277 - 6281
Опубликована: Янв. 1, 2024
A
method
for
the
synthesis
of
thiocarbamates
catalyzed
by
Na
2
CO
3
from
isocyanates
and
thiols
was
developed,
possible
mechanism
proposed.
This
has
advantages
high
yield,
good
tolerance,
atom
economy
mild
conditions.
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Herein,
we
have
described
a
novel
organocatalytic
approach
to
access
biologically
important
dihydropyridin-2-ones
in
one-pot
way
with
generally
high
yields
(up
99%)
and
excellent
enantioselectivities
99%
ee).
This
reaction
proceeded
