La(OTf)3-Catalyzed Benzannulation of 2-Arylidene-1H-indene-1,3(2H)-diones with Enamino Esters: Direct Access to Functionalized Fluorenone Derivatives
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
An
attractive
method
for
the
preparation
of
functional
fluorenone
derivatives
has
been
developed
via
La(OTf)3-catalyzed
benzannulation
2-arylidene-1H-indene-1,3(2H)-diones
with
enamino
esters.
The
reaction
involves
Michael
addition,
intramolecular
cyclization,
dehydration,
and
aromatization
in
a
one-step
process
affords
wide
range
moderate
to
good
yields.
Moreover,
this
protocol
provides
several
advantages,
including
broad
substrate
scope,
readily
available
materials,
high
atom
economy,
applicability
large-scale
synthesis.
Язык: Английский
Catalytic Decarbonylative Functionalization of C–H Bonds with Carboxylic Acids
Synlett,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Abstract
Within
the
past
decades,
potential
of
transition-metal-catalyzed
cross-coupling
reactions
using
carboxylic
acids
as
coupling
partners
has
been
subjected
to
extensive
exploitation
because
natural
abundance,
ready
availability,
nontoxicity,
stability,
structural
diversity,
and
low
cost
acids.
Notably,
recent
years
have
witnessed
intense
research
interest
in
combination
decarbonylation
with
direct
C–H
bond
functionalization
presence
transition-metal
catalysts
for
formation
various
C–C
bonds
release
CO.
The
approach
presents
a
powerful
alternative
existing
repertoire
via
formation.
In
this
Account,
we
highlight
our
achievements
development
decarbonylative
under
catalysis.
1
Introduction
2
Arylation
Aryl
Carboxylic
Acids
3
Alkenylation
Alkenyl
4
Alkylation
Alkyl
5
Conclusion
Outlook
Язык: Английский
Highly Efficient Esterification of Carboxylic Acids with O-H Nucleophiles through Acid/Iodide Cooperative Catalysis
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(30), С. 6181 - 6188
Опубликована: Янв. 1, 2024
The
esterification
of
carboxylic
acids
is
an
important
reaction
for
preparing
esters
which
find
wide
applications
in
various
research
fields.
In
this
manuscript,
we
report
acid/iodide
cooperative
catalytic
method
enables
highly
efficient
with
a
range
equivalent
O-H
nucleophiles
including
both
alcohols
and
weak
nucleophilic
phenols.
Under
the
conditions,
aromatic
aliphatic
those
bearing
functional
groups
work
well,
furnishing
corresponding
good
to
high
yields.
Moreover,
scalable
applicable
modification
bioactive
molecules.
These
results
demonstrate
synthetic
value
new
organic
synthesis.
Язык: Английский
Catalytic Asymmetric Synthesis of Chiral Fluorenes: Recent Developments and Future Perspectives
Tianyuan Ou,
Liming Xiang,
Ying Zhou
и другие.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(46)
Опубликована: Авг. 26, 2024
Abstract
The
chiral
fluorene
fragment
constitutes
one
of
the
most
important
scaffolds
frequently
found
in
numerous
bioactive
molecules,
ligands,
and
advanced
functional
materials
due
to
its
unique
physical
properties.
In
this
context,
various
transition
metal‐
organo‐catalyzed
asymmetric
reactions
have
been
developed
prepare
fluorenes
with
high
optical
purity.
present
mini‐review,
we
summarize
fifteen
years
achievements
catalytic
synthesis
their
derivatives.
Particular
attention
is
given
strategies
used
mechanistic
aspects
some
significant
reactions.
Moreover,
cutting‐edge
developments
silafluorenes
are
also
highlighted.
Язык: Английский