Synthesis of Thiohydantoin Scaffolds on DNA for Focused DNA-Encoded Library Construction
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 3, 2024
Thiohydantoin
represents
a
significant
class
of
biologically
active
privileged
heterocyclic
scaffolds.
Herein,
we
present
convenient
and
robust
DNA-compatible
method
for
constructing
thiohydantoin-focused
DNA-encoded
library.
This
reaction
can
be
applied
to
wide
variety
isothiocyanate
partners,
arylamine
feedstocks,
diverse
α-amine
acid
derivatives,
exhibiting
excellent
conversions,
high
functional
group
tolerance,
preservation
DNA
tag
integrity.
Our
allows
easy
access
valuable
three-cycle
Язык: Английский
On-DNA Three-Component Cycloaddition of Diazo Compounds, Nitrosoarenes, and Alkenes: Syntheses of Isoxazolidines for DNA-Encoded Chemical Libraries
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
A
DNA-compatible
three-component
reaction
is
disclosed
for
the
synthesis
of
on-DNA
polysubstituted
isoxazolidines
that
serve
as
privileged
core
scaffolds
in
numerous
natural
products
and
bioactive
molecules.
This
one-pot
approach
involves
1,3-dipolar
cycloaddition
DNA-tagged
styrenes
with
diazo
compounds
nitrosoarenes
an
aqueous
solution
KOAc.
The
demonstrates
excellent
functional
group
compatibility,
providing
a
conventional
protocol
construction
DNA-labeled
isoxazolidine
library.
Язык: Английский