Electrochemical Deaminative Carboxylation of Aryltriazenes with CO₂ to Aryl Carboxylic Acids

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

The utilization of CO2 as an appealing chemical feedstock for diverse synthetically valuable products is constantly evolving, potentially alleviating production that relies on petrochemistry. Herein we report the first example electrochemical deaminative carboxylation aryltriazenes with CO2. reaction can be performed under mild and catalyst-free conditions by using sustainable methods a green C1 building block, efficiently converting range readily available into carboxylic acids. In particular, formation C-C bonds would impactful addition to synthesis toolbox.

Язык: Английский

Iodide/Nickel Co-Catalyzed Manganese-Mediated Denitrogenative Cross-Electrophile Coupling of Benzotriazinones with Alkyl Sulfonates

Molecules, Год журнала: 2025, Номер 30(11), С. 2397 - 2397

Опубликована: Май 30, 2025

An efficient Ni-catalyzed, Mn-mediated denitrogenative cross-electrophile coupling of N-alkyl-1,2,3-benzotriazinones with alkyl tosylates and mesylates for access to o-alkyl secondary benzamides is reported. The method uses inexpensive non-anhydrous dimethyl acetamide (DMA) in combination tetrabutyl ammonium iodide (TBAI) as a co-catalyst convert sulfonates into iodides situ. Scope limitations the protocol have been demonstrated by >30 examples yields up 91%, showing large electronic effect from N-substituent benzotriazinones. unexpected steric acceleration has observed core benzotriazinones, not only promising highly 2-alkyl-2,3-disubstituted but also shedding light on rate-limiting steps catalytic cycle.

Язык: Английский