Cited by Late-Stage C-H Trifluoroacetylation of Quinoxaline-2(1<i>H</i>)-ones Using Masked Trifluoroacyl Reagents

Electrochemical Strategy for the Radical Fluoroacetylation of Sulfoximines from Fluorinated Alkyl Carboxylic Acids DOI

Xiaoman Li, Jiawei Huang, Huanhuan Song

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

The integration of trifluoroacetyl (CF3CO) groups into organic skeletons is a key research topic in synthetic chemistry given their significant potential to boost biological activity. Despite recent developments strategies for incorporating moiety via radical intermediates, the practical utilization inexpensive and readily available trifluoroacetic acids as sources has not yet been developed. Herein, an electrochemical strategy employed achieve deoxygenative transformation directly with assistance PPh3. obtained radicals are then coupled sulfoximine species, thus enabling synthesis N-trifluoroacetylated sulfoximines. Additionally, other fluorinated alkyl carboxylic acids, including perfluoro-, difluoro-, trifluoromethylcarboxylic can also be efficiently utilized under these conditions, leading corresponding acylated Moreover, trifluoroacetylation drug-based molecules easy execution scale-up experiments highlight applicability this protocol.

Язык: Английский

Процитировано

Enantioselective 1,2-Carboamination of 1,3-Dienes with N-Hydroxyphthalimide (NHP) Esters Enabled by a Photoinduced Pd Catalysis DOI

Zhilin Liu,

Jia-Le Yan,

Kai Chen

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Herein, a photoinduced, Pd-catalyzed direct 1,2-carboamination of conjugated 1,3-dienes has been successfully achieved. Sequential regioselective C-C bond and enantioselective C-N formation allows rapid assembly wide range value-added chiral allylic amines from readily available

Язык: Английский

Процитировано

A facile access to aliphatic trifluoromethyl ketones via photocatalyzed cross-coupling of bromotrifluoroacetone and alkenes DOI

Satoshi Mizuta, Tomoko Yamaguchi,

Masaharu Iwasaki

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This manuscript discloses the visible-light photocatalytic radical addition into olefins using bromotrifluoroacetone as trifluoroacetonyl precursor.

Язык: Английский

Процитировано

Late-Stage C-H Trifluoroacetylation of Quinoxaline-2(1H)-ones Using Masked Trifluoroacyl Reagents DOI

Yawei Shen, Li Yuan, Xia Wang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

A strategy for trifluoroacetylation of quinoxaline-2(1 H )-ones has been investigated.

Язык: Английский

Процитировано