Palladium-Catalyzed Asymmetric Tandem Carbonylation–Heck Reaction of Cyclopentenes to Access Chiral Bicyclo[3.2.1]octenes DOI

Pengyun Liu,

Hongyue Dong,

Baihui Gong

и другие.

Organic Letters, Год журнала: 2024, Номер 26(39), С. 8244 - 8248

Опубликована: Сен. 23, 2024

A palladium-catalyzed asymmetric tandem carbonylation-Heck reaction of cyclopentenes with carbon monoxide (CO) has been disclosed. This desymmetrization procedure afforded a series bicyclo[3.2.1]octenes one chiral quaternary and tertiary center in good yields enantioselectivities. proceeds via an acyl-palladium intermediate, followed by migratory insertion the alkenes.

Язык: Английский

Enantioselective Synthesis of Hydrindanes via Palladium-Catalyzed Asymmetric Desymmetrization of Cyclohexadiene Derivatives DOI

Shu Sen Wu,

Miaomiao Li,

Jiajun Lu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

We herein disclose a strategy for the asymmetric desymmetrization of cyclohexadiene derivatives via palladium-catalyzed Heck and tandem Heck/Tsuji-Trost allylic alkoxylation reaction. By employing DCE as solvent, we obtained variety chiral hydrindanes containing an all-carbon quaternary carbon center tertiary in good yields with excellent enantioselectivities. With alcohols valuable one stereocenter two centers were constructed high level enantioinduction.

Язык: Английский

Процитировано

1
Palladium-Catalyzed Cascade Carbonylation Reaction To Construct Ester Derivatives DOI
Ming Li,

Shan-Mei Xu,

Fei Yang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

We have developed a palladium-catalyzed ester carbonylation reaction that enables the synthesis of ester-substituted benzofuran derivatives in single step through introduction alkyl halides undergoing situ hydrolysis and alkynyl aryl iodides. This method demonstrates broad applicability to both primary secondary while maintaining excellent functional group compatibility under low palladium loading conditions. Notably, this strategy significantly expands scope reactions.

Язык: Английский

Процитировано

1
Enantioselective Synthesis of P-Chiral Phosphine Oxides Bearing an All-Carbon Quaternary Stereogenic Center via Palladium-Catalyzed Domino Heck–Suzuki Reaction DOI
Siyu Zhao, Jiahao Liu,

Xunfang Xu

и другие.

ACS Catalysis, Год журнала: 2024, Номер unknown, С. 14762 - 14768

Опубликована: Сен. 20, 2024

Язык: Английский

Процитировано

5
Catalytic construction of P-stereogenic center via phosphorus-centered nucleophilic substitution DOI
Bingbing Dong, Junmin Zhang, Xiang-Yu Ye

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111052 - 111052

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Enantio- and Diastereoselective Synthesis of P-Stereogenic Phospholane Oxides via Cobalt-Catalyzed Hydroalkylation DOI
Dao‐Yong Zhu, Yating Zhang,

Fu Cheng

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis synthesis. However, the construction of chiral skeleton remains challenging primarily relies on use auxiliaries or resolution. In this work, a highly enantioselective diastereoselective synthesis P-stereogenic oxides has achieved through cobalt-catalyzed desymmetric hydroalkylation strategy. This method enables two discrete stereocenters with excellent yields enantiomeric excesses.

Язык: Английский

Процитировано

0
Palladium-Catalyzed Asymmetric Tandem Carbonylation–Heck Reaction of Cyclopentenes to Access Chiral Bicyclo[3.2.1]octenes DOI

Pengyun Liu,

Hongyue Dong,

Baihui Gong

и другие.

Organic Letters, Год журнала: 2024, Номер 26(39), С. 8244 - 8248

Опубликована: Сен. 23, 2024

A palladium-catalyzed asymmetric tandem carbonylation-Heck reaction of cyclopentenes with carbon monoxide (CO) has been disclosed. This desymmetrization procedure afforded a series bicyclo[3.2.1]octenes one chiral quaternary and tertiary center in good yields enantioselectivities. proceeds via an acyl-palladium intermediate, followed by migratory insertion the alkenes.

Язык: Английский

Процитировано

0