Synergistic Pd/Ni Dual-Catalyzed Cross-Coupling of Azaaryl Acetates with gem-Difluorinated Cyclopropanes
Organic Letters,
Год журнала:
2024,
Номер
26(41), С. 8956 - 8960
Опубликована: Окт. 7, 2024
We
herein
report
the
development
of
a
novel
Pd/Ni
dual-catalyzed
ring-opening
functionalization
Язык: Английский
Pd-IPent-Catalyzed Defluorinative Annulation of gem-Difluorocyclopropanes with Enamides: Synthesis of Multisubstituted N-H Pyrroles
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
We
present
a
Pd-IPent-catalyzed
ring-opening
defluorinative
annulation
reaction
of
gem-difluorocyclopropanes
with
enamides,
which
provides
convenient
and
efficient
strategy
for
the
synthesis
multisubstituted
N-H
pyrrole
derivatives.
This
transformation
selectively
cleaves
C1-C3
bond,
two
C-F
bonds,
C-N
bond
in
one-pot
procedure.
Additionally,
this
protocol
allows
modification
several
bioactive
molecules.
Язык: Английский
Palladium-Catalyzed Dearomative Fluoroallylation of Pyrroles with gem-Difluorinated Cyclopropanes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
We
herein
report
the
development
of
a
novel
Pd-catalyzed
dearomative
functionalization
pyrroles
with
gem-difluorinated
cyclopropanes
(gem-F2CPs).
This
dearomative/ring-opening
strategy
streamlines
diversity-oriented
synthesis
(DOS)
α-quaternary
2-fluoroallylic
2H-pyrroles
broad
scope
and
excellent
functional
group
tolerance,
which
enables
efficient
late-stage
transformation
complex
bioactive
molecule-derived
gem-F2CPs.
Derivation
resulting
fluoroallylic
to
different
synthetically
useful
2H-pyrrole
motifs
demonstrated
synthetic
value
this
methodology.
Язык: Английский
Palladium-Catalyzed Ring-Opening Defluorinative Hiyama Cross-Coupling of gem-Difluorocyclopropanes with Arylsilanes
Zimin Wang,
Daniel C. Hong,
Hongfang Li
и другие.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
We
report
an
efficient
palladium-catalyzed
ring-opening
defluorinative
Hiyama
cross-coupling
of
gem-difluorocyclopropanes
with
structurally
diverse
(hetero)arylsilanes
through
C-C
bond
activation
and
C-F
cleavage.
This
regioselective
features
a
broad
substrate
scope
excellent
functional
group
compatibility,
affording
variety
linear
2-fluoroallylic
scaffolds
in
good
yields
high
Z-selectivity.
Язык: Английский
Palladium-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane
Chinese Chemical Letters,
Год журнала:
2025,
Номер
unknown, С. 111288 - 111288
Опубликована: Май 1, 2025
Язык: Английский
Palladium(II)-Catalyzed Enantioselective Ring Opening of Oxabenzonorbornadienes via Domino Aminopalladation of Alkynylanilines
Organic Letters,
Год журнала:
2024,
Номер
27(1), С. 369 - 375
Опубликована: Дек. 30, 2024
We
report
herein
a
robust
enantioselective
ring
opening
coupling
of
oxabenzonorbornadienes
via
Pd(II)-catalyzed
domino
cyclization
alkynylanilines,
which
features
the
formation
three
covalent
bonds
and
two
contiguous
stereocenters
with
excellent
enantio-
diastereoselectivity
broad
substrate
scope.
The
good
functional
group
tolerance
this
desymmetrization
strategy
enables
efficient
late-stage
transformation
natural
product-derived
alkynylanilines.
resulting
indolated
dihydronaphthols
could
serve
as
valuable
platform
to
streamline
diversity-oriented
synthesis
other
enantioenriched
tetrahydronaphthalene
derivatives.
Язык: Английский