Perhaloacylation of α-Carbonyl Sulfoxonium Ylides
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
A
mild
and
efficient
protocol
for
the
perhaloacylation
of
α-carbonyl
sulfoxonium
ylides
has
been
developed.
The
commercially
available
perfluoro-
perchloroacid
anhydrides
were
used
as
acylating
agents
in
catalyst-
additive-free
reactions
to
access
α-carbonyl-α'-perhaloacyl
high
yields.
reaction
offers
a
simple
method
prepare
valuable
polyfluorinated
organosulfur
molecules.
Язык: Английский
Divergent Construction of α,α-Difunctionalized Ketones via [1,2]-Sigmatropic Rearrangement/Alkylation-Hydroxylation/Dialkylation of I(III)/S(VI) Ylides
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
rare
[1,2]-sigmatropic
rearrangement
of
sulfoxonium-iodonium
hybrid
ylides
is
described,
which
enables
the
efficient
sulfoxidation/sulfonylation-alkylation
I(III)/S(VI)
with
1,3-dicarbonyls.
By
slight
modification
reaction
conditions,
controllable
alkylation-hydroxylation
and
dialkylation
were
achieved.
This
strategy
affords
a
diverse
array
α,α-difunctionalized
ketones
in
moderate
to
good
yields,
demonstrating
broad
substrate
scope.
These
findings
provide
an
important
advancement
sulfoxonium
highlight
divergent
reactivity
ylides.
Язык: Английский
Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides
Haiting Wu,
Yougen Xu,
Lin An
и другие.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Amide
and
alkene
moieties
are
frequently
found
in
natural
products
privileged
structures
pharmaceuticals
agrochemicals.
Moreover,
vinyl
sulfoxonium
ylide
can
be
converted
into
a
broad
range
of
high-value
compounds,
thus
they
have
been
widely
employed
organic
synthesis.
However,
the
synthesis
alkene-substituted
amide-sulfoxonium
ylides
via
intermolecular
hydrocarbonation
alkynes
remains
underexplored.
This
study
describes
development
high-throughput
approach
to
provide
diverse
functionalized
E-alkene
substituted
(hetero)amide-sulfoxonium
ylides.
The
reaction
occurs
under
mild
metal-free
conditions,
employing
as
highly
effective
nucleophiles,
which
participate
Michael
addition
reactions
with
various
alkynes,
such
esters,
thioesters,
ketones,
amides,
sulfones.
low-cost,
operationally
simple
has
substrate
scope,
high
functional
group
compatibility,
excellent
regio-
stereoselectivity,
making
it
suitable
for
transformation
structurally
complex
molecules.
Furthermore,
obtained
stabilized
directly
useful
valuable
1,5-dicarbonyl
thiabenzene
1-oxide
compounds.
Язык: Английский
Modular Synthesis of Divergent Thiofunctionalized Sulfoxonium Ylides
Qiong Hu,
Mei-Zhu Bao,
Yuanjie Meng
и другие.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
metal-free
protocol
for
the
modular
synthesis
of
diverse
α-thiofunctionalized-α′-carbonyl
sulfoxonium
ylides
from
sulfoxonium–iodonium
hybrid
(I
(III)
/S
(VI)
-ylides)
has
been
achieved.
Язык: Английский
Synthesis of α-Carbonyl-α′-sulfenyl Sulfoxonium Ylides in Water at Room Temperature
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(21), С. 15523 - 15528
Опубликована: Окт. 19, 2024
An
efficient
synthesis
of
α-carbonyl-α'-sulfenyl
sulfoxonium
ylides
through
a
KIO
Язык: Английский
Recent Advances on the Construction of Functionalized Indolizine and Imidazo[1,2‐a]pyridine Derivatives
The Chemical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
Abstract
Indolizines
and
imidazo[1,2‐
a
]pyridines
are
commonly
found
in
natural
products,
synthetic
drugs,
bioactive
molecules.
These
two
types
of
derivatives
possess
good
antibacterial,
antiparasitic,
anticancer
activities,
so
on.
The
functionalization
indolizines
has
always
been
hot
topic
organic
chemistry
research
made
significant
progress.
In
recent
years,
our
group
dedicated
to
developing
diverse
methods
for
the
preparation
such
important
compounds.
1)
We
have
developed
C−H
reactions
efficient
modification
parent
]pyridines.
2)
A
variety
cycloaddition
were
established
construction
indolizine
]pyridine
from
simple
raw
materials.
3)
intriguing
deconstruction‐functionalization
indolizines,
enabling
reorganization
heterocyclic
frameworks.
This
paper
outlines
group's
latest
advancements
constructing
structurally
derivatives.
hope
that
this
work
will
offer
valuable
insights
inspiration
ongoing
field
N‐heterocyclic
Язык: Английский
Silver-Mediated Radical Cascade Trifluoromethylthiolation/Cyclization of Benzimidazole Derivatives with AgSCF3
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
silver-mediated
cascade
trifluoromethylthiolation/cyclization
of
unactivated
alkenes
has
been
investigated.
This
strategy
employs
AgSCF
Язык: Английский