Rh(III)-Catalyzed [4 + 2] Annulation and Dehydrogenative Annulation of N-Chloroimines with Maleimides

The Journal of Organic Chemistry, Год журнала: 2025, Номер 90(4), С. 1706 - 1719

Опубликована: Янв. 15, 2025

We herein report a Rh(III)-catalyzed C–H bond coupling of N-chloroimines with maleimides, in which the [4 + 2] annulation and dehydrogenative processes can be selectively achieved by simply adjusting reaction conditions. This protocol is compatible various functional groups, shows exquisite selectivity, presents concise synthetic procedure to respective products moderate good yields. With all these merits, this strategy may applicable construction related azaheterocyclic skeletons.

Язык: Английский

Iridium(III)-Catalyzed Cyclization of Oximes with Iodonium Ylides: Synthesis of Multisubstituted Heterocyclic N-Oxides

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Iridium(III)-catalyzed regioselective cyclization of substituted oximes with iodonium ylides has been described. This methodology offered multisubstituted heterocyclic N-oxides under mild reaction conditions in a redox-neutral manner. The was also compatible vinyl oximes. Additionally, substrate diversification carried out to illustrate the synthetic application protocol. A possible mechanism involving C-H bond activation proposed as well supported by isolation key five-membered iridacycle intermediate.

Язык: Английский