Palladium-Catalyzed Site-Selective C–H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
We
presented
a
highly
efficient
palladium-catalyzed
site-selective
C-H
sulfonylation
reaction
via
aryl
thianthrenium
salts.
By
utilizing
readily
available
and
cost-effective
arenes
along
with
sodium
sulfinates,
we
achieved
the
C(sp2)-S
cross-coupling
high
efficiency,
establishing
dependable
method
for
synthesizing
diarylsulfones
satisfactory
yields.
This
exhibits
excellent
tolerance
toward
functional
groups,
scalability,
synthesis
or
late-stage
functionalization
of
bioactive
molecules,
making
it
valuable
tool
drug
modifications.
Язык: Английский
Palladium-Catalyzed Hiyama Cross-Coupling of Heterocyclic Phosphonium Salts with Arylsilanes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
We
report
herein
the
palladium-catalyzed
Hiyama
cross-coupling
of
heterocyclic
phosphonium
salts
with
diverse
(hetero)arylsilanes
through
C-P
bond
cleavage,
providing
an
alternative
approach
for
highly
regioselective
functionalization
pyridines
and
relevant
nitrogen-containing
heterocycles.
This
silicon-based
protocol
is
amenable
to
gram-scale
synthesis
also
applicable
late-stage
pharmaceutically
complex
molecules.
Язык: Английский
Palladium-catalyzed carbene C–H insertion reaction of non-activated arenes
Chinese Chemical Letters,
Год журнала:
2025,
Номер
unknown, С. 111225 - 111225
Опубликована: Апрель 1, 2025
Язык: Английский
Nickel-Catalyzed Gas-Free Reductive Carbonylation of Aryl Thianthrenium Salts to Access Aryl Amides and Aryl Thioesters
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
A
nickel-catalyzed
site-selective
reductive
carbonylation
of
arenes
via
aryl
thianthrenium
salts
is
described.
Using
Mo(CO)6
as
a
convenient
solid
CO
source
and
reductant
employing
nitroarenes
sulfonyl
chlorides
readily
available
nitrogen
sulfur
sources,
range
amides
thioesters
were
successfully
synthesized
in
moderate
to
good
yields.
The
utility
this
transformation
demonstrated
through
the
synthesis
antimicrobial
agents
late-stage
functionalization
biorelevant
molecules.
Язык: Английский
Stabilized Carbon Radical‐Mediated Assembly of Arylthianthrenium Salts, Alkenes and Amino Acid/Peptide Derivatives
Advanced Science,
Год журнала:
2024,
Номер
12(2)
Опубликована: Ноя. 21, 2024
Abstract
Efficiently
assembling
amino
acids
and
peptides
with
bioactive
molecules
facilitates
the
modular
streamlined
synthesis
of
a
diverse
library
peptide‐related
compounds.
Particularly
notable
is
their
application
in
pharmaceutical
development,
leveraging
site‐selective
late‐stage
functionalization.
Here,
visible
light‐induced
three‐component
reaction
involving
arylthianthrenium
salts,
acid/peptide
derivatives,
alkenes
are
introduced.
This
approach
utilizes
captodatively‐stabilized
carbon
radicals
to
enable
radical‐radical
C─C
coupling,
effectively
constructing
complex
molecules.
method
offers
promising
alternative
route
for
peptide‐derived
bio‐relevant
compounds
Язык: Английский