Catalytic Enantioselective Aldol Reactions of Pyruvates as Nucleophiles with Chlorinated and Fluorinated Aldehydes and Ketones DOI
Santanu Mondal, Fujie Tanaka

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 15972 - 15978

Опубликована: Окт. 23, 2024

Reactions of pyruvates as nucleophiles under catalytic conditions are difficult to control without the use enzymes catalysts. Here, enantioselective aldol reactions with chlorinated and fluorinated aldehydes ketones organocatalytic conditions, in which act nucleophiles, reported. Based on analyses self-aldol presence model catalysts, catalysts desired cross were developed. Using primary amine-derived catalyst, products, i.e., γ-chlorinated alkyl or γ-fluorinated group-substituted γ-hydroxy α-ketoesters, obtained good high yields enantioselectivities.

Язык: Английский

Catalytic Enantioselective Aldol Reactions of Pyruvates as Nucleophiles with Chlorinated and Fluorinated Aldehydes and Ketones DOI
Santanu Mondal, Fujie Tanaka

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 15972 - 15978

Опубликована: Окт. 23, 2024

Reactions of pyruvates as nucleophiles under catalytic conditions are difficult to control without the use enzymes catalysts. Here, enantioselective aldol reactions with chlorinated and fluorinated aldehydes ketones organocatalytic conditions, in which act nucleophiles, reported. Based on analyses self-aldol presence model catalysts, catalysts desired cross were developed. Using primary amine-derived catalyst, products, i.e., γ-chlorinated alkyl or γ-fluorinated group-substituted γ-hydroxy α-ketoesters, obtained good high yields enantioselectivities.

Язык: Английский

Процитировано

2