Cu-Catalyzed Relay Functionalization of Alkenes: Diverse Synthesis of Diazidated Quinazolinones and Polycyclic Imidazoles
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
A
Cu-catalyzed
relay
process
for
the
preparation
of
diazidated
quinazolinone
and
polycyclic
imidazole
derivatives
in
which
readily
available
alkene-tethered
substrates
undergo
an
addition/cyclization/C(sp3)–H
functionalization
alkene
sequences
with
high
efficiency
is
described.
Various
functionalized
N-heteropolycyclic
compounds
were
prepared
good
yields
a
broad
substrate
scope.
Moreover,
direct
azidation
α-C(sp3)–H
bond
corresponding
N-heterocycles
has
been
demonstrated
on
basis
mechanistic
studies,
provide
alternative
late-stage
approach
derivatization
N-heterocyclic
scaffolds.
Язык: Английский
Electron-Donor-Mediated Divergent Transformation of Br–RF via EDA Complex for the Synthesis of Fluorine-Containing Oxindoles and Amides
Organic Letters,
Год журнала:
2024,
Номер
26(46), С. 9990 - 9995
Опубликована: Ноя. 11, 2024
We
have
developed
an
unprecedented
electron-donor-controlled
divergent
reaction
between
Язык: Английский
Recent Progress in C–S Bond Formation via Electron Donor-Acceptor Photoactivation
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
summarizes
recent
progress
in
EDA
complex-promoted
C–S
bond
formation
using
various
sulfur-containing
substrates
under
mild
conditions
via
visible
light
irradiation.
Язык: Английский
Thiolative Annulation of N-Benzyl-N-cyanopropiolamides Leading to Divergent Synthesis of Pyrroloquinazolin-1-ones and Maleimides
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
An
unprecedented
successive
radical-promoted
thiolative
annulation/Pd-catalyzed
C-H
amination
of
N-benzyl-N-cyanopropiolamides
to
access
pyrrolo[2,1-b]quinazolin-1(9H)-ones
in
a
one-pot
manner
is
described.
Moreover,
altering
the
step
with
oxidation
(reagent
switch)
offered
maleimides
from
same
set
readily
accessible
precursors.
Both
transformations
display
versatility
across
wide
range
substrates,
enabling
efficient
various
functionalized
quinazolin-1-ones
and
good
yields.
Язык: Английский
Photoinduced Metal‐Free Decarboxylative Fluoroalkylation of Alkenes for the Synthesis of N‐Arylbutanamides and Oxindoles
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(68)
Опубликована: Авг. 28, 2024
The
visible
light-induced
decarboxylative
cascade
reaction
of
fluoroalkyl
carboxylic
acids
has
been
achieved
for
the
efficient
synthesis
fluorinated
compounds.
However,
most
transformations
rely
on
noble
iridium
metal
complex.
Herein,
a
metal-free
realized.
This
protocol
features
simple
operation,
transition
free,
and
good
functional
group
tolerance.
Язык: Английский