Palladium-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane DOI

Junqi Su,

Wenhao Liu, Jianjun Wang

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111288 - 111288

Опубликована: Май 1, 2025

Язык: Английский

Rhodium-Catalyzed Asymmetric Allylic Dearomatization of β-Naphthols with gem-Difluorinated Cyclopropanes DOI
Ziqi Yang,

Yiliang Gong,

Qing Gu

и другие.

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 4287 - 4293

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

3
Pd-IPent-Catalyzed Defluorinative Annulation of gem-Difluorocyclopropanes with Enamides: Synthesis of Multisubstituted N-H Pyrroles DOI
Wenhao Liu,

Yahui Ma,

Qiuwei Huang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

We present a Pd-IPent-catalyzed ring-opening defluorinative annulation reaction of gem-difluorocyclopropanes with enamides, which provides convenient and efficient strategy for the synthesis multisubstituted N-H pyrrole derivatives. This transformation selectively cleaves C1-C3 bond, two C-F bonds, C-N bond in one-pot procedure. Additionally, this protocol allows modification several bioactive molecules.

Язык: Английский

Процитировано

0
Palladium-Catalyzed Dearomative Fluoroallylation of Pyrroles with gem-Difluorinated Cyclopropanes DOI
Long Gu, Fajie Duan,

Jiafeng Ye

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

We herein report the development of a novel Pd-catalyzed dearomative functionalization pyrroles with gem-difluorinated cyclopropanes (gem-F2CPs). This dearomative/ring-opening strategy streamlines diversity-oriented synthesis (DOS) α-quaternary 2-fluoroallylic 2H-pyrroles broad scope and excellent functional group tolerance, which enables efficient late-stage transformation complex bioactive molecule-derived gem-F2CPs. Derivation resulting fluoroallylic to different synthetically useful 2H-pyrrole motifs demonstrated synthetic value this methodology.

Язык: Английский

Процитировано

0
Palladium-Catalyzed Ring-Opening Defluorinative Hiyama Cross-Coupling of gem-Difluorocyclopropanes with Arylsilanes DOI

Zimin Wang,

Daniel C. Hong,

Hongfang Li

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

We report an efficient palladium-catalyzed ring-opening defluorinative Hiyama cross-coupling of gem-difluorocyclopropanes with structurally diverse (hetero)arylsilanes through C-C bond activation and C-F cleavage. This regioselective features a broad substrate scope excellent functional group compatibility, affording variety linear 2-fluoroallylic scaffolds in good yields high Z-selectivity.

Язык: Английский

Процитировано

0
Palladium-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane DOI

Junqi Su,

Wenhao Liu, Jianjun Wang

и другие.

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111288 - 111288

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0