Applications of innovative synthetic strategies in anticancer drug Discovery: The Driving Force of new chemical reactions
Bioorganic & Medicinal Chemistry Letters,
Год журнала:
2025,
Номер
119, С. 130096 - 130096
Опубликована: Янв. 9, 2025
Язык: Английский
Synthesis of Benzoisochromene Derivatives via C–H Activation-Initiated Cascade Formal [4+2] and [2+4] Annulation of Aryl Enaminone with Vinyl-1,3-dioxolan-2-one
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Cascade
annulation
reactions
can
assemble
structurally
intricate
polycyclic
molecules
from
simple
starting
materials
with
enhanced
efficiency
and
minimized
production
of
waste.
Presented
herein
is
a
concise
effective
synthesis
benzoisochromene
derivatives
based
on
C-H
activation-initiated
cascade
formal
[4+2]/[2+4]
aryl
enaminone
vinyl-1,3-dioxolan-2-one.
In
constructing
the
six-membered
carbocycle,
acted
as
C4
synthon
while
vinyl-1,3-dioxolan-2-one
C2
synthon.
O-heterocycle,
other
hand,
former
latter
C3O1
To
our
knowledge,
this
first
simultaneous
construction
both
carbocycle
an
O-heterocycle
via
concurrent
C-H/C-N/C-O
bond
cleavage
C-C/C-C/C-O
formation.
general,
novel
protocol
features
use
readily
obtainable
substrates
broad
scope,
excellent
atom-
step-economy,
intriguing
reaction
pathway,
valuable
products.
Язык: Английский
Unveiling the Synthesis of Indole-Fused Eight-Membered Aza-Heterocycles via FeCl3–Catalyzed Radical C–N Coupling and Photophysical Studies
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
A
novel
strategy
toward
construction
of
indole-fused
eight-membered
heterocyclic
rings
through
a
radical
pathway
has
been
reported.
Our
approach
involves
tandem
cyclization
via
FeCl3-catalyzed
cross-dehydrogenative
double
C–N
bond
formation
using
DDQ
as
an
oxidant
under
mild
condition.
An
EPR
experiment
and
time
course
1H
NMR
study
confirm
that
the
addition
triggers
pyrazole
N-radical,
which
contributes
to
eight-member
framework
with
good
yield.
The
structural
diversity
synthetic
utility
have
explored,
along
photophysical
properties
synthesized
compounds.
Язык: Английский
Catalytic System-Controlled [4 + 1] and [4 + 2] Annulation for the Construction of Pyrazolo[1,2-a]indazoles and Pyrazolo[1,2-a]cinnolines from Pyrazolidinones and Diazo Indandiones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 13, 2025
Pyrazolo[1,2-a]indazoles
and
pyrazolo[1,2-a]cinnolines
can
be
constructed
selectively
via
catalytic
system-controlled
C(sp2)-H
activation/[4
+
1]
cyclization
2]
reaction,
utilizing
pyrazolidinones
diazo
indandiones.
Employing
two
different
Rh(III)
catalysts,
we
successfully
synthesized
distinct
types
of
nitrogen-containing
heterocyclic
compounds,
pyrazolo[1,2-a]indazoles
pyrazolo[1,2-a]cinnolines,
respectively.
Moreover,
an
inexpensive
Ru(II)
catalyst
could
also
effectively
generate
with
moderate
to
good
yields.
Overall,
these
methodologies
offer
advantages
such
as
regioselectivity,
broad
substrate
scope,
operational
simplicity,
product
availability.
Язык: Английский
Advancements in hydroxyapatite synthesis and surface modifications for emerging biomedical applications
Inorganic Chemistry Communications,
Год журнала:
2024,
Номер
170, С. 113414 - 113414
Опубликована: Ноя. 4, 2024
Язык: Английский
Synthesis of [4.6] Spirocarbocycles: A Base-promoted Ring-Expansion and Subsequent I2-mediated Regioselective Spirocyclization Protocol
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(23), С. 6797 - 6803
Опубликована: Янв. 1, 2024
An
efficient
protocol
for
the
synthesis
of
[4.6]
spirocarbocycles
by
reacting
cyclic
β-ketoesters
with
aryl-fused
1,6-diyn-3-ones
has
been
developed.
Язык: Английский
Synthesis of Functionalized Indoles by an Iridium-Catalyzed N–H Insertion Cascade: Nucleophilic Cyclization of Naphthylamines with α-Diazocarbonyl Compounds
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
A
novel
iridium-catalyzed
[3
+
2]
annulation
of
naphthylamines
and
α-diazocarbonyl
compounds
was
developed
for
the
rapid
assembly
densely
functionalized
indoles.
This
new
catalytic
process
represents
first
example
a
cascade
intramolecular
nucleophilic
cyclization
by
N-H
insertion
amines.
Various
could
be
obtained
in
high
yields
with
excellent
functional
group
tolerance.
The
reaction
affords
valuable
indole
derivatives,
enabling
expedient
access
to
heterocyclic
analogues
not
easily
accessible
other
methods.
Язык: Английский
Triple C–H Activation/Annulation: In Situ Construction of Fluorescent Peptides
Zhefan Zhang,
Tianyan Wan,
Qi Quan
и другие.
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Herein,
we
report
a
Rh(III)-catalyzed
triple
C-H
activation-annulation
of
Phe-based
peptides
with
alkynes
for
the
preparation
fluorescent
peptides.
The
robustness
this
protocol
is
reflected
by
broad
substrate
scope,
high
atom-
and
step-economy,
excellent
chemo-
site-selectivity.
An
in
situ
generated
polycyclic
aromatic
hydrocarbon
carbocation
as
fluorophore
exhibits
good
fluorescence
properties
(maximum
emission
wavelength
up
to
628
nm)
low
cell
cytotoxicity.
synthetic
utility
method
further
demonstrated
versatile
product
applications
bioconjugation
protein
BSA
specifically
targeting
lysosomes
mitochondria
live
mammalian
cells.
Язык: Английский