Direct Cross-Couplings of Aryl Nonaflates with Aryl Bromides under Nickel Catalysis
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
The
direct
cross-couplings
of
aryl
nonaflates
with
bromides
could
be
successfully
accomplished
by
utilizing
nickel
as
the
catalyst,
magnesium
metal
mediator,
and
lithium
chloride
additive.
reactions
proceeded
efficiently
in
THF
at
room
temperature
to
produce
desired
biaryls
moderate
good
yields,
showing
both
a
reasonable
substrate
scope
functional
group
tolerance.
Additionally,
an
equally
performance
realized
when
reaction
was
subjected
scale-up
synthesis.
Preliminary
study
suggested
that
presumably
proceeds
through
situ
formation
arylmagnesium
reagent
key
intermediate.
Язык: Английский
Magnesium-Mediated Three-Component Reductive Cross-Couplings of Aryl Aldehydes, Aryl Bromides, and Aryl 2-Pyridyl Esters: An Efficient Synthesis of Diarylmethanol Esters
Tetrahedron,
Год журнала:
2025,
Номер
unknown, С. 134558 - 134558
Опубликована: Фев. 1, 2025
Язык: Английский
β-Thioamide Sulfone Enabled Copper-Catalyzed Ring-Opening/Sulfonylation of Cyclopropenes: Access to Alkyl Aryl Sulfones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Sulfone
motifs
play
important
roles
in
bioactive
compounds
and
functional
materials.
The
development
of
efficient
methodologies
for
constructing
sulfonyl-containing
has
thus
attracted
considerable
attention.
Here,
we
introduce
a
protocol
the
preparation
alkyl
aryl
sulfones
under
mild
conditions.
This
employs
β-thioamide
sulfone
as
novel
motif
donor.
It
forms
sulfinates
situ
basic
conditions,
which
then
undergo
cross-coupling
with
intermediates
that
were
generated
from
ligand-free
copper-catalyzed
cyclopropenes
(CPEs)
ring
opening.
Язык: Английский
Palladium-Catalyzed Hiyama Cross-Coupling of Heterocyclic Phosphonium Salts with Arylsilanes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
We
report
herein
the
palladium-catalyzed
Hiyama
cross-coupling
of
heterocyclic
phosphonium
salts
with
diverse
(hetero)arylsilanes
through
C-P
bond
cleavage,
providing
an
alternative
approach
for
highly
regioselective
functionalization
pyridines
and
relevant
nitrogen-containing
heterocycles.
This
silicon-based
protocol
is
amenable
to
gram-scale
synthesis
also
applicable
late-stage
pharmaceutically
complex
molecules.
Язык: Английский
Sulfonylation of 2-Haloquinolines with Sulfonyl Hydrazides in Water for Accessing 2-Sulfonyl Quinolines under Catalyst-, Reductant-, and Additive-Free Conditions
Bo‐Jie Huo,
Yuan-Shuai Wu,
Chengping Miao
и другие.
Tetrahedron,
Год журнала:
2025,
Номер
unknown, С. 134705 - 134705
Опубликована: Май 1, 2025
Язык: Английский
Palladium-Catalyzed Decarboxylative Cross-Couplings of Zinc Polyfluorobenzoates with Aryl 2-Pyridyl Esters for Accessing Polyfluorinated Aryl Ketones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
An
efficient
decarboxylative
cross-coupling
of
zinc
polyfluorobenzoate
with
aryl
2-pyridyl
ester
under
palladium
catalysis,
which
enabled
the
convenient
access
to
valuable
polyfluorinated
ketones,
was
developed.
The
reactions
proceeded
effectively
give
an
array
ketones
in
moderate
excellent
yields
a
reasonable
substrate
scope
and
broad
functional
group
tolerance.
In
addition,
one-pot
reaction
use
situ
formed
commencing
from
polyfluorobenzoic
acid
Zn(OH)2
could
be
accomplished
as
well
step-economical
fashion.
Moreover,
coupling
protocol
also
successfully
subjected
scale-up
synthesis
readily
applied
late-stage
functionalization
biologically
active
complex
molecules.
Язык: Английский
Iron‐Mediated Desulfonylative Cross‐Electrophile Couplings of Heteroaryl Sulfones with Thiosulfonates for Efficient Synthesis of Heteroaryl Sulfides
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Comprehensive
Summary
A
desulfonylative
thiolation
between
heteroaryl
sulfones
and
thiosulfonates
for
the
efficient
synthesis
of
sulfides
was
developed.
The
cross‐electrophile
couplings
proceeded
effectively
via
old
C–SO
2
bond
cleavage
new
C–S
formation
in
presence
cheapest
widely
available
iron
powder
as
mediator
under
transition
metal
catalyst‐free
conditions,
leading
to
a
wide
array
derived
from
benzo[
d
]thiazole,
]oxazole,
thiazole,
1,3,4‐thiadiazole,
1
H
‐tetrazole
modest
excellent
yields.
In
addition,
reaction
exhibited
good
functional
group
compatibility,
protocol
could
also
be
applicable
use
selenosulfonate
substrate
subjected
scale‐up
with
equal
ease.
Notably,
unreacted
readily
recovered
after
by
resorting
attracting
property
magnetic
stir
bar
iron.
Язык: Английский