Bifunctional NHC-Catalyzed Asymmetric Intramolecular Conjugate Addition via Noncovalent Interaction
Ujjwal Maji,
Arpita Baidya,
Supriyo Das
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Herein,
we
report
a
novel
squaramide
containing
chiral
bifunctional
N-heterocyclic
carbene
(NHC)
and
its
utilization
in
developing
asymmetric
intramolecular
conjugate
addition
involving
noncovalent
interaction.
Via
concomitant
activation
of
both
electrophilic
nucleophilic
centers
substrates,
the
reaction
proceeds
through
well-organized
transition
state,
thereby
affording
products
with
up
to
94%
ee
broad
scope.
The
process
is
found
be
scalable.
initial
mechanistic
study
supports
nature
newly
designed
NHC.
Язык: Английский
A Flash Conversion to Aromatic Azo Compounds Expedited by Hydrazine–Trifluoroacetate Hydrogen Bonding
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Aromatic
azo
compounds
are
very
useful
chemicals,
but
rapid
and
safe
synthetic
methods
for
preparing
these
underexplored.
An
extremely
fast
reaction
was
developed
to
prepare
aromatic
from
commercially
available
quinones
aryl
hydrazinium
chloride
salts.
The
reactions
could
be
completed
within
2
min,
in
the
presence
of
sodium
trifluoroacetate
under
ambient
conditions.
A
hydrazine-trifluoroacetate
hydrogen
bonding
complex
likely
inhibited
byproducts
greatly
accelerated
reaction.
overall
procedure
is
simple
does
not
require
sophisticated
organic
equipment
techniques.
Язык: Английский