Synthesis of Functionalized 1H-Imidazoles via Denitrogenative Transformation of 5-Amino-1,2,3-Triazoles DOI Creative Commons
Pavel S. Gribanov, Anna N. Philippova, Alexander F. Smol’yakov

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1401 - 1401

Опубликована: Март 21, 2025

An efficient access to novel 2-substituted 1H-imidazole derivatives was developed based on acid-mediated denitrogenative transformation of 5-amino-1,2,3-triazole available through dipolar azide−nitrile cycloaddition (DCR). The proposed approach includes intramolecular cyclization 5-amino-4-aryl-1-(2,2-diethoxyethyl) 1,2,3-triazoles followed by triazole ring opening and insertion in situ formed carbene intermediate into the O-H bond different alcohols under acidic conditions.

Язык: Английский

Synthesis of Functionalized 1H-Imidazoles via Denitrogenative Transformation of 5-Amino-1,2,3-Triazoles DOI Creative Commons
Pavel S. Gribanov, Anna N. Philippova, Alexander F. Smol’yakov

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1401 - 1401

Опубликована: Март 21, 2025

An efficient access to novel 2-substituted 1H-imidazole derivatives was developed based on acid-mediated denitrogenative transformation of 5-amino-1,2,3-triazole available through dipolar azide−nitrile cycloaddition (DCR). The proposed approach includes intramolecular cyclization 5-amino-4-aryl-1-(2,2-diethoxyethyl) 1,2,3-triazoles followed by triazole ring opening and insertion in situ formed carbene intermediate into the O-H bond different alcohols under acidic conditions.

Язык: Английский

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