g-C3N4-Based Heterogeneous Photocatalyzed Synthesis and Evaluation of Antitumor Activities of Fluoroalkylated 4H-Pyrido[1,2-a]pyrimidin-4-ones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
The
first
example
of
heterogeneous
photoredox-catalyzed
fluoroalkylation
4H-pyrido[1,2-a]pyrimidin-4-ones
has
been
developed.
With
low-cost
commercial
g-C3N4
as
the
recyclable
photocatalyst
and
cheap
sodium
fluoroalkyl
sulfonates
source,
a
variety
fluoroalkylated
pyridopyrimidinones
were
constructed
in
moderate
to
high
yields.
present
reaction
can
be
easily
scaled
up
with
good
efficiency,
catalytic
system
reused
5
times
slight
loss
activities.
Furthermore,
biological
activity
synthesized
compounds
was
preliminarily
investigated.
Язык: Английский
Fe-Catalyzed Radical Trifluoromethylation and Cyclization of Ortho-Vinyl Enaminones with 1-(Trifluoromethyl)-1,3-benzo-[d][1,2]iodaoxol-3(1H)-one to Construct Functionalized Quinolines
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
Herein,
we
present
a
protocol
for
the
construction
of
functionalized
quinolines,
i.e.,
3-acyl-4-(2,2,2-trifluoro-ethyl)quinolines
(ATFQLs)
4,
from
ortho-vinyl
enaminones
and
1-(trifluoromethyl)-1,3-benzo-[d][1,2]-iodaoxol-3(1H)-one,
which
was
catalyzed
by
FeCp2
promoted
FeCl3
(Lewis
acid)
additives
in
solvents
(i.e.,
acetonitrile
toluene).
This
strategy
first
utilized
FeCp2-catalyzed
functionalization
alkenes
with
trifluoromethyl
radicals.
The
intermediate
formed
captured
ortho-iodobenzoate
substrate,
yielding
3,
then
underwent
FeCl3-catalyzed
elimination
at
higher
temperature
to
form
an
α,β-unsaturated
intermediate.
subsequent
intramolecular
Michael
reaction
yielded
final
target
compound
4.
In
summary,
series
ATFQLs
4
were
synthesized
through
formation
two
bonds
(C═C
C-C).
Язык: Английский
EDA Complex-Mediated Aerobic Three-Component CDC Reactions of Quinoxalinones under Visible-Light Irradiation
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
A
visible-light-induced
Minisci-type
three-component
aerobic
cross-dehydrogenative
coupling
(CDC)
reaction
of
quinoxalinones
with
styrenes
and
acetophenones
is
described.
The
catalytic
electron
donor-acceptor
(EDA)
complexation
TMSCl
found
to
be
the
key
for
oxygen
activation,
which
initiates
oxidative
radical
formation
under
photocatalyst-free
conditions.
This
protocol
provides
facile
efficient
access
structurally
valuable
highly
functionalized
generally
high
chemoselectivity
moderate
good
yields.
Язык: Английский