Nickel-Catalyzed Electroreductive Heck Reaction: A Divergent Synthesis of C7- or C2-Arylindolines

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Herein, we present a novel electrochemically driven nickel-catalyzed Heck reaction of readily available N-arylacrylindoles for the construction both 7-arylindolines and 2-arylindolines. The proceeds in an undivided electrochemical cell employs sacrificial zinc anode as reductant. This catalytic protocol features consecutive electroreductive process under exceedingly mild conditions, with moderate yields. Detailed mechanistic studies indicate that involves domino sequence intramolecular arylation selective C-C or C-O bond cleavage, which could be accomplished by aryl migration carbethoxy removal.

Язык: Английский

Photoelectrochemistry-Promoted Ni-Catalyzed C–O Cross-Couplings

Precision Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский