Enantiospecific Synthesis of α-Tertiary Amines: Ruthenium-Catalyzed Allylic Amination with Aqueous Ammonia DOI
Sven M. Papidocha, Henrik R. Wilke, Kacper J. Patej

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Ammonia stands out as the most available, cost-effective, and atom-economical source of nitrogen for organic synthesis. In laboratory, it is safely conveniently handled in aqueous solution. Despite advantages, direct application ammonia field transition-metal catalysis remains a significant challenge. this study, we report first ruthenium-catalyzed allylic substitution using ammonia. The catalytic system, consisting [Cp*Ru(MeCN)3]PF6 phenoxythiazoline ligand, enables enantiospecific amination tertiary carbonates media affords enantioenriched primary amines single regioisomers high yields.

Язык: Английский

Synthesis of vinyl, alkyl-substituted chiral acrylates via Krische iridium complex-catalysed allylic phosphonation DOI
Yuanyuan Zhang, Yi Deng, Kun Wei

и другие.

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

An enantioselective preparation of vinyl, alkyl-substituted chiral α-stereogenic acrylates is reported using two consecutive steps Ir-catalysed allylic alkylation aliphatic acetates with phosphonates and HWE olefination.

Язык: Английский

Процитировано

0
Enantiospecific Synthesis of α-Tertiary Amines: Ruthenium-Catalyzed Allylic Amination with Aqueous Ammonia DOI
Sven M. Papidocha, Henrik R. Wilke, Kacper J. Patej

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Ammonia stands out as the most available, cost-effective, and atom-economical source of nitrogen for organic synthesis. In laboratory, it is safely conveniently handled in aqueous solution. Despite advantages, direct application ammonia field transition-metal catalysis remains a significant challenge. this study, we report first ruthenium-catalyzed allylic substitution using ammonia. The catalytic system, consisting [Cp*Ru(MeCN)3]PF6 phenoxythiazoline ligand, enables enantiospecific amination tertiary carbonates media affords enantioenriched primary amines single regioisomers high yields.

Язык: Английский

Процитировано

0