Synthesis of CF3-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF3-Imidoyl Sulfoxonium Ylides
Molecules,
Год журнала:
2025,
Номер
30(1), С. 183 - 183
Опубликована: Янв. 5, 2025
An
efficient
Rh(III)-catalyzed
C-H
activation
of
azobenzenes
and
subsequent
[4+1]
cascade
annulation
with
CF3-imidoyl
sulfoxonium
ylides
was
developed,
yielding
diverse
CF3-indazoles.
This
protocol
featured
easily
available
starting
materials,
excellent
functional
group
tolerance
high
efficiency.
Moreover,
the
antitumor
activities
selected
CF3-indazoles
against
human
cancer
cell
lines
were
also
studied,
results
indicated
that
several
compounds
displayed
considerable
antiproliferative
activities.
Язык: Английский
Modular Synthesis of Monofluorinated 1,2,4-Triazoles/1,3,5-Triazines via Defluorinative Annulations of N-CF3 Imidoyl Chlorides
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Ring-fluorinated
azaheterocycles
have
wide
applications
in
agrochemicals,
pharmaceuticals,
and
synthesis,
which
prompt
continuous
endeavors
to
expand
such
heterocyclic
families.
However,
monofluorinated
triazaheterocycles
hardly
been
explored.
This
work
reported
a
novel
modular
synthesis
of
1,2,4-triazoles
1,3,5-triazines,
utilizes
N-CF3
imidoyl
chlorides
as
unique
polyfluoro
synthons
their
defluorinative
annulations
with
hydrazines/imidazines.
Further
modifications
these
fluorinated
heterocycles
highlight
the
potential
method
for
accessing
functional
molecules.
Язык: Английский