PVP‐I Catalyzed Hydroxysulfurization of α‐(Trifluoromethyl)‐Styrenes with Thiols: Access to Trifluoromethyl Tertiary Alcohol
ChemistrySelect,
Год журнала:
2025,
Номер
10(6)
Опубликована: Фев. 1, 2025
Abstract
An
efficient
method
for
the
synthesis
of
β
‐hydroxy‐
‐CF
3
‐thioether
has
been
developed,
utilizing
povidone‐iodine
(PVP‐I)
as
a
recyclable
catalyst
and
air
oxidant.
The
reaction
proceeded
smoothly
at
room
temperature,
yielding
desired
in
moderate
to
good
yields.
This
can
be
scaled
up
gram‐scale
without
losing
any
efficiency.
was
also
8
repetitions.
mechanism
investigated
plausible
pathway
proposed.
Язык: Английский
Photocatalyzed/Base-Mediated Defluorinative Three-Component Cascade Cyclization: Access to Monofluorocyclohexenes and 6-Fluoro-1,2,3,4-tetrahydropyridines
Shuyue Zhang,
Meixue Gan,
Fan Zhang
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
A
three-component
cascade
cyclization
of
α-CF3
alkenes,
electron-rich
and
dimethyl
esters
or
sulfonamides
via
a
dual
C–F
bond
cleavage
process
is
described.
This
methodology
provides
general
efficient
strategy
to
access
monofluorocyclohexenes
6-fluoro-1,2,3,4-tetrahydropyridines
by
switching
the
bifunctional
reagents
(dimethyl
sulfonamides),
which
are
valuable
building
blocks
in
synthetic
chemistry
pharmaceutical
industries.
The
reaction
mechanism
applications
products
have
been
demonstrated.
Язык: Английский