Iron–Cobalt Dual Catalysis for the Synthesis of Alkenyl Amino Acids and Modification of Peptides DOI

Huan-Huan Zhao,

Xu-Gang Zhang,

Haowen Jiang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Herein, we report an Fe/Co dual-catalyzed strategy for synthesizing alkenyl unnatural amino acids and peptide modifications. This approach utilizes aspartic acid glutamic derivatives as alkyl radical precursors. It avoids the use of expensive photoredox catalysts substrate preactivation while preserving chirality acids. Furthermore, this enables both modification peptides synthesis amino-acid-based drug candidates boron-neutron capture therapy (BNCT).

Язык: Английский

Iron–Cobalt Dual Catalysis for the Synthesis of Alkenyl Amino Acids and Modification of Peptides DOI

Huan-Huan Zhao,

Xu-Gang Zhang,

Haowen Jiang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Herein, we report an Fe/Co dual-catalyzed strategy for synthesizing alkenyl unnatural amino acids and peptide modifications. This approach utilizes aspartic acid glutamic derivatives as alkyl radical precursors. It avoids the use of expensive photoredox catalysts substrate preactivation while preserving chirality acids. Furthermore, this enables both modification peptides synthesis amino-acid-based drug candidates boron-neutron capture therapy (BNCT).

Язык: Английский

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