Photocatalyzed Annulation‐Biselenylation of Enynone with Diarylselenides toward Biselenium‐Substituted 1‐Indanones under Metal‐ and Photosensitizer‐Free Conditions
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Comprehensive
Summary
A
practical
photocatalytic
annulation‐biselenylation
strategy
has
been
developed
for
the
efficient
synthesis
of
biselenium‐substituted
1‐indanones
(38
examples
in
total)
with
generally
good
yields
(up
to
95%)
and
excellent
stereoselectivity
(>19
:
1
Z
/
E
ratio)
by
employing
enynones
diaryl
selenides
as
starting
materials
under
photosensitizer‐free
conditions.
The
reaction
mechanism
involves
a
cascade
process
comprising
homolytic
cleavage,
radical
addition,
5‐
exo
‐
dig
cyclization,
capture,
enabling
sequential
formation
multiple
bonds,
such
C(sp
3
)‐Se,
)‐C(sp
2
),
)‐Se
rapidly
construct
molecular
complexity.
Notably,
this
approach
demonstrates
wide
substrate
compatibility
tolerability
towards
various
functional
groups.
It
is
further
characterized
its
remarkable
efficiency
creating
chemical
bonds
achieving
high
atomic
utilization
100%.
Язык: Английский
Synthetic Strategies Toward 2H‐, 4H‐Pyrans, and Pyranones: Recent Advances
ChemistrySelect,
Год журнала:
2025,
Номер
10(21)
Опубликована: Май 30, 2025
Abstract
Pyrans
are
a
class
of
six‐membered
heterocyclic
rings
containing
five
carbon
atoms
and
one
oxygen
atom.
They
non‐aromatic
in
nature,
bearing
two
double
bonds
the
ring.
The
bond
position
distinguishes
pyran
isomers,
namely,
2
H
‐pyran
4
‐pyran.
When
saturated
sp
3
is
located
next
to
an
atom,
it
known
as
‐pyran,
when
at
4‐position
with
respect
In
1962,
by
thermal
breakdown
2‐acetoxy‐3,4‐dihydro‐2
‐pyrans
were
produced
for
first
time,
their
characteristics
explored.
Numerous
synthetic
methods
have
been
disclosed
over
time
owing
broad
applications
diverse
fields,
mainly
drug
design,
pharmaceuticals,
material
science.
this
review,
we
highlight
recent
advancements
toward
substituted
4‐pyranone,
2‐pyranones,
focusing
on
reports
published
from
2019
till
date,
which
play
important
roles
both
organic
synthesis
types
functional
molecules.
Язык: Английский