Merging Paired Electrolysis and Copper Catalysis Enables Electrochemical Arylation of Aziridine for the Synthesis of 1,2-Amino Tertiary Alcohols DOI

Zhong-Shan Teng,

Yu‐Rong Yang,

Xin-Yu Zhang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

1,2-Amino alcohols are omnipresent in bioactive molecules. Conventional approaches to this motif require multistep reactions. Herein, we develop an electrochemical strategy for copper-catalyzed convergent paired electrolysis. By selectively cleaving the C-N bond of 2-aryl-1-tosylaziridines with electron-deficient aromatics as aryl source, 1,2-amino tertiary alcohol scaffold is rapidly constructed. This method features mild reaction conditions, large-scale preparation, and a lack sacrificial electrodes. Experimental studies DFT calculations indicate that tends toward radical cross-coupling.

Язык: Английский

Merging Paired Electrolysis and Copper Catalysis Enables Electrochemical Arylation of Aziridine for the Synthesis of 1,2-Amino Tertiary Alcohols DOI

Zhong-Shan Teng,

Yu‐Rong Yang,

Xin-Yu Zhang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

1,2-Amino alcohols are omnipresent in bioactive molecules. Conventional approaches to this motif require multistep reactions. Herein, we develop an electrochemical strategy for copper-catalyzed convergent paired electrolysis. By selectively cleaving the C-N bond of 2-aryl-1-tosylaziridines with electron-deficient aromatics as aryl source, 1,2-amino tertiary alcohol scaffold is rapidly constructed. This method features mild reaction conditions, large-scale preparation, and a lack sacrificial electrodes. Experimental studies DFT calculations indicate that tends toward radical cross-coupling.

Язык: Английский

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