
Chemical Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
In this study, we report the first development of metal catalyzed methylthiolation chloroarenes and diverse aromatic electrophiles, addressing persistent challenges catalyst intermediate deactivation in functionalization less reactive substrates. To overcome these issues, designed a novel anion-shuttle-type agent, 4-((methylthio)methyl)morpholine, which enables controlled situ release methylthiolate anions, thereby preventing poisoning enhancing reactivity. This strategy allows efficient not only but also broad range aryl including bromoarenes, triflates, tosylates, pivalates, nitriles, carboxylic acids. The developed system exhibits excellent functional group compatibility, making it applicable to derivatization pharmaceuticals natural products. Furthermore, detailed mechanistic investigations revealed key factors underlying exceptional efficiency providing new insights into C-S bond formation under practical conditions.
Язык: Английский