Palladium-Catalyzed Regioselective [3 + 2] Annulation with N-Allenamides at the Proximal C═C Bond: Synthesis of γ-Amino-α′-methylenecyclopentenones DOI
Yidong Wang,

Hang Zhou,

Yan Sun

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

A palladium-catalyzed [3 + 2] cycloaddition of cyclopropenones with N-allenamides has been developed. This methodology facilitates the synthesis γ-amino-α'-methylenecyclopentenones in moderate to excellent yields good regioselectivity and compatibility various functional groups. The employment as versatile 2C synthons enables simultaneous incorporation both a nitrogen atom methylene group into cyclopentenones. Furthermore, this approach exhibits reverse when compared general allenes. Density theory calculations successfully elucidated origin observed regioselectivity.

Язык: Английский

Palladium-Catalyzed Regioselective [3 + 2] Annulation with N-Allenamides at the Proximal C═C Bond: Synthesis of γ-Amino-α′-methylenecyclopentenones DOI
Yidong Wang,

Hang Zhou,

Yan Sun

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

A palladium-catalyzed [3 + 2] cycloaddition of cyclopropenones with N-allenamides has been developed. This methodology facilitates the synthesis γ-amino-α'-methylenecyclopentenones in moderate to excellent yields good regioselectivity and compatibility various functional groups. The employment as versatile 2C synthons enables simultaneous incorporation both a nitrogen atom methylene group into cyclopentenones. Furthermore, this approach exhibits reverse when compared general allenes. Density theory calculations successfully elucidated origin observed regioselectivity.

Язык: Английский

Процитировано

0