Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions DOI Creative Commons
Francesco Soddu,

Iktedar Mahdi,

Maria Chiara Cabua

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalization with various electrophiles single, continuous flow process. This method eliminates need laborious temperature changes cryogenic conditions, significantly reduces process time from starting material to products. Compared traditional batch processes, our enables use single organolithium reagent operates efficiently at 0 °C, avoiding cool-warm-cool cycles typical methods. not only simplifies workflow but also enhances practicality, scalability, extends accessible chemical space.

Язык: Английский

Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions DOI Creative Commons
Francesco Soddu,

Iktedar Mahdi,

Maria Chiara Cabua

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalization with various electrophiles single, continuous flow process. This method eliminates need laborious temperature changes cryogenic conditions, significantly reduces process time from starting material to products. Compared traditional batch processes, our enables use single organolithium reagent operates efficiently at 0 °C, avoiding cool-warm-cool cycles typical methods. not only simplifies workflow but also enhances practicality, scalability, extends accessible chemical space.

Язык: Английский

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