The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
A facile method with simple starting materials, including enaminones, α-diazo esters, and nitriles, has been developed for the direct synthesis of N,N-diacyl glycine esters via visible light photocatalysis. The reaction involves a novel carbon-carbon bond cleavage in leading to products high tolerance variability substructures among all three components.
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 25, 2025
Abstract The rapid assembly of diverse cyclic amines from simple precursors is now considered as an ideal platform with respect to efficiency and sustainability. To date, numerous synthetic methods have been successfully developed however, most them are limited a narrow subset amines, variations in ring size often requiring different substrates distinct strategies. Furthermore, the “escape‐from‐Flatland” concept has led chemists focus on synthesis C(sp 3 )‐rich small molecules for potential drug candidates. Herein, successful realization radical‐polar crossover bicyclization reaction reported easily available cyclopropylamines substituted alkenes through photoredox catalysis. This approach introduces innovative methodology de novo collection 4/5‐, 5/5‐, 6/5‐,7/5‐, 5/6‐fused saturated bicyclic systematic modular manner excellent diastereoselectivity. work highlights utility photoinduced radical–polar bicyclization, applicability which showcased by functional group tolerance, wide substrate scopes, derivatization reactions.
Язык: Английский
Процитировано
1
Molecular Catalysis, Год журнала: 2025, Номер 580, С. 115086 - 115086
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Май 12, 2025
A palladium-catalyzed three-component coupling of 2-arylaziridines, α-diazo esters, and cyclic ethers, affording tertiary enamides with excellent regio- stereoselectivity, is reported. This regioselective ring-opening aziridines different from the classical transition-metal/phosphine catalyzed ones. broad spectrum substrates tolerated (up to 33 examples). An ortho-aryl substituent on naphthyl ring 1,1'-bi-2-naphthol (BINOL)-derived phosphoramidite ligand critical for this coupling, additional diphosphine (DPEphos) can further enhance reactivity. Mechanistic studies suggest that 10-membered 9-membered palladacycle intermediates may be formed followed by twice reversible β-H eliminations.
Язык: Английский
Процитировано
0
Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Herein, an efficient aerobic cross-coupling of quinoxazolines with electron-rich thiophenes was presented. It's easy and effective access to 3-thiophenyl quinoxalinones without external photo-catalyst or transition-metal catalyst.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
Transition-metal-free synthesis of diversely substituted 4-sulfenyl-5-aminopyrazoles was developed under mild conditions through NaI-mediated three-component reaction β-ketonitriles, disulfides, and hydrazines. The pyrazole products were constructed via consecutive cleavage C-O S-S bonds recombination C-N C-S bonds. methodology features broad substrate scope, transition-metal-free conditions, easy manipulation.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
A facile method with simple starting materials, including enaminones, α-diazo esters, and nitriles, has been developed for the direct synthesis of N,N-diacyl glycine esters via visible light photocatalysis. The reaction involves a novel carbon-carbon bond cleavage in leading to products high tolerance variability substructures among all three components.
Язык: Английский
Процитировано
0