Copper-Catalyzed Regio- and Enantioselective Hydroamination of gem-Difluoroalkenes to Access Chiral Difluoromethyl Amines DOI
Ming Yu Jin, Yuanyuan Guo, Hao Wu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

The difluoromethyl group (CF2H) is an important motif in medicinal chemistry. We report the efficient synthesis of a range optically pure α-difluoromethyl amines via copper-catalyzed regio- and enantioselective hydroamination gem-difluoroalkenes. application chiral pyridine-derived ligand inhibits β-F elimination from α-CF2H organocopper intermediate. proposed Cu catalyst promotes production by Cu-H insertion reductive C-N bond using readily available materials. findings this study establish new synthetic strategy to access motifs.

Язык: Английский

Nickel-Catalyzed Regioselective Ring-Opening Hydroarylation of Methylenecyclopropanes DOI
Aili Fan, Xinyi Li, Jinyang Chen

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

The hydroarylation of methylenecyclopropanes (MCPs) is a challenging process due to the difficulty in controlling regioselectivity and complex reaction patterns involved. Herein, we report simple external ligand-free Ni-catalyzed ring-opening MCPs with high efficiency unprecedented regioselective arylation as well broad functional group tolerance by using inexpensive aryl boronic acids source. synthetic utility has been demonstrated for facile preparation versatile highly valued products. Mechanistic studies suggest that Ni(II)-H, formed via oxidative addition Ni(0) proton system, might act key intermediate.

Язык: Английский

Процитировано

0

Copper-Catalyzed Regio- and Enantioselective Hydroamination of gem-Difluoroalkenes to Access Chiral Difluoromethyl Amines DOI
Ming Yu Jin, Yuanyuan Guo, Hao Wu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

The difluoromethyl group (CF2H) is an important motif in medicinal chemistry. We report the efficient synthesis of a range optically pure α-difluoromethyl amines via copper-catalyzed regio- and enantioselective hydroamination gem-difluoroalkenes. application chiral pyridine-derived ligand inhibits β-F elimination from α-CF2H organocopper intermediate. proposed Cu catalyst promotes production by Cu-H insertion reductive C-N bond using readily available materials. findings this study establish new synthetic strategy to access motifs.

Язык: Английский

Процитировано

0