Nickel-Catalyzed Regioselective Ring-Opening Hydroarylation of Methylenecyclopropanes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
The
hydroarylation
of
methylenecyclopropanes
(MCPs)
is
a
challenging
process
due
to
the
difficulty
in
controlling
regioselectivity
and
complex
reaction
patterns
involved.
Herein,
we
report
simple
external
ligand-free
Ni-catalyzed
ring-opening
MCPs
with
high
efficiency
unprecedented
regioselective
arylation
as
well
broad
functional
group
tolerance
by
using
inexpensive
aryl
boronic
acids
source.
synthetic
utility
has
been
demonstrated
for
facile
preparation
versatile
highly
valued
products.
Mechanistic
studies
suggest
that
Ni(II)-H,
formed
via
oxidative
addition
Ni(0)
proton
system,
might
act
key
intermediate.
Язык: Английский
Copper-Catalyzed Regio- and Enantioselective Hydroamination of gem-Difluoroalkenes to Access Chiral Difluoromethyl Amines
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
The
difluoromethyl
group
(CF2H)
is
an
important
motif
in
medicinal
chemistry.
We
report
the
efficient
synthesis
of
a
range
optically
pure
α-difluoromethyl
amines
via
copper-catalyzed
regio-
and
enantioselective
hydroamination
gem-difluoroalkenes.
application
chiral
pyridine-derived
ligand
inhibits
β-F
elimination
from
α-CF2H
organocopper
intermediate.
proposed
Cu
catalyst
promotes
production
by
Cu-H
insertion
reductive
C-N
bond
using
readily
available
materials.
findings
this
study
establish
new
synthetic
strategy
to
access
motifs.
Язык: Английский