The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

The incorporation of the pentafluorosulfanyl (SF5) group into organic molecules is highly significant due to its unique physicochemical properties and potential applications in pharmaceuticals agrochemicals. However, general efficient methods for synthesis benzylic SF5-containing compounds remain unexplored. Herein, we report a series 2-(pentafluorosulfanyl)methyl benzophenones via insertion arynes C-C σ-bond α-pentafluorosulfanyl ketones. This transition-metal-free reaction proceeds under mild conditions with high regioselectivity good functional tolerance, as demonstrated by 21 examples.

Язык: Английский