Angewandte Chemie,
Год журнала:
2018,
Номер
130(42), С. 13928 - 13941
Опубликована: Июнь 6, 2018
Abstract
Funktionalisierte
cyclische
organische
Carbonate
und
deren
heterocyclischen
Derivate
sind
eine
sehr
vielseitige
Gruppe
heterocyclischer
Substrate,
katalytische
Ringöffnung
Decarboxylierung
die
Entwicklung
neuartiger
Synthesewege
zur
Herstellung
stereo‐
enantioselektiver
C‐N‐,
C‐O‐,
C‐C‐,
C‐S‐
C‐B‐Bindungen
ermöglicht.
Erst
kürzlich
wurden
Übergangsmetall‐vermittelte
Umwandlungen
als
wirksame
Methode
Synthese
komplexerer
Moleküle
wiederentdeckt.
Dieser
Kurzaufsatz
illustriert
das
Potential
cyclischer
ihrer
strukturell
verwandten
Heterocyclen,
mit
einem
besonderen
Fokus
auf
dem
synthetischen
Nutzen
der
mechanistischen
Mannigfaltigkeit
Umwandlungen.
RSC Advances,
Год журнала:
2023,
Номер
13(13), С. 8657 - 8682
Опубликована: Янв. 1, 2023
4-Quinolone
and
its
analogs
are
heterocyclic
classes
of
organic
compounds
displaying
biologically
active
a
broad
spectrum
pharmaceutical
drug
scaffolds.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(7), С. 4833 - 4838
Опубликована: Март 22, 2023
A
facile
and
practical
method
for
the
synthesis
of
fused
tricyclic
pyrazolo[5,1-a]isoquinolines
has
been
realized
via
reactions
enaminones,
hydrazine
hydrochloride,
internal
alkynes.
By
means
Rh
catalysis,
extraordinary
high-order
bond
functionalization,
including
transformation
aryl
C–H,
ketone
C═O,
alkenyl
C–N
bonds
in
marks
major
feature
cascade
reactions.
The
results
disclose
individual
advantage
enaminones
design
novel
efficient
synthetic
methods.
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
Abstract
The
applicability
of
enaminones
is
based
on
its
reactivity
allowing
usage
the
compound
in
other
than
nucleophilic
addition
and
cyclization
processes.
Recent
literature
revealed
several
novel
reactions
that
expand
their
synthetic
usage.
As
perhaps
one
most
unusual
emerging
patterns
are
engagements
intramolecular
ability
to
form
heterocycles
at
mild
conditions.
Functionalized
also
demonstrate
activity
with
different
electrophiles,
including
alkylating
agents
as
well
carbonyl
compounds,
making
bond
formation
cannot
be
easily
predicted.
Further,
undergo
redox‐active
type
transformations
oxidative
coupling
construction
C─N
bonds,
which
direct
synthesis
polyfunctional
amines
nitrogen‐containing
frameworks.
They
participate
radical
processes
such
cross‐coupling
polymerization
reactions,
expanding
spectrum.
These
unprecedented
provide
us
new
strategies
for
building
up
sophisticated
molecular
architectures
functional
materials.
This
review
focuses
trends
constructing
classes
compounds
suggests
perspectives
subsequent
studies
advance
chemistry.
Advanced Synthesis & Catalysis,
Год журнала:
2017,
Номер
360(2), С. 379 - 384
Опубликована: Ноя. 24, 2017
Abstract
Iridium(III)‐catalyzed
highly
regiocontrolled
C3/C8
amidation
of
isoquinolones
and
C6
2‐pyridones
has
been
successfully
accomplished
with
various
azides.
The
optimized
method
is
operationally
simple
a
broad
substrate
scope.
protocol
found
to
be
scalable.
magnified
image
Advanced Synthesis & Catalysis,
Год журнала:
2018,
Номер
360(9), С. 1800 - 1804
Опубликована: Март 25, 2018
Abstract
Ball
milling
techniques
have
been
applied
in
the
development
of
a
mechanosynthesis
[Cp*Co(CO)I
2
],
which
proved
highly
efficient
as
catalyst
mechanochemical
C−H
bond
amidations
indoles
mixer
ball
mill.
A
wide
range
amidated
products
is
obtained
excellent
yields.
Compared
to
solution‐based
methods,
procedure
opens
more
feasible
and
environmentally‐friendly
access
both
cobalt(III)
2‐amidated
indoles.
magnified
image
Organic Letters,
Год журнала:
2018,
Номер
20(3), С. 660 - 663
Опубликована: Янв. 11, 2018
A
one-step
methodology
for
the
synthesis
of
multisubstituted
quinoline-4-carboxamides
was
developed
by
simply
refluxing
a
mixture
isatins
1
and
various
kinds
1,1-enediamines
2–4
in
reaction
catalyzed
NH2SO3H.
As
result,
series
quinolone-4-carboxamides
were
produced
through
novel
cascade
mechanism.
This
involved
formation
quinoline
ring
accompanied
an
amide
bond
one
step.
Accordingly,
this
protocol
is
suitable
combinatorial
parallel
syntheses
quinolone-4-carboxamide
drugs
or
natural
products.
Organic Letters,
Год журнала:
2019,
Номер
21(4), С. 951 - 954
Опубликована: Янв. 25, 2019
The
amide-directed
cobalt(III)-catalyzed
C–H
amidation
of
ferrocene
carboxamides
using
1,4,2-dioxazol-5-ones
as
robust
and
efficient
amidating
reagents
has
been
developed.
This
reaction
proceeds
efficiently
under
mild
conditions
with
good
functional
group
tolerance,
providing
expedient
access
to
a
broad
range
ferrocenes
containing
nitrogen
on
the
Cp
ring.
Organic Letters,
Год журнала:
2021,
Номер
23(11), С. 4406 - 4410
Опубликована: Май 21, 2021
A
novel
Rh(III)-catalyzed
C–H
activation/annulation
cascade
of
indole-enaminones
with
diazo
compounds
was
reported
to
construct
diversely
functionalized
carbazole
frameworks.
The
most
notable
characteristic
is
that
this
transformation
could
smoothly
furnish
a
[5
+
1]
cyclization
product
good
excellent
yields
(up
95%),
accompanied
by
the
thorough
removal
acetyl
and
N,N-dimethyl
groups
two
substrates
from
target
products,
rather
than
normally
expected
[4
2]
products.
