Angewandte Chemie,
Год журнала:
2018,
Номер
130(39), С. 13112 - 13116
Опубликована: Июль 2, 2018
Abstract
We
report
the
successful
generation
of
(diborylmethyl)zinc(II)
species
by
transmetallation
beteween
isolable
(diborylmethyl)lithium
and
zinc(II)
halide
(X=Br,
Cl)
their
application
in
synthesis
enantioenriched
gem
‐diborylalkanes
bearing
a
stereogenic
center
at
β‐position
diboryl
groups
an
asymmetric
allylic
substitution
reaction.
The
reaction
has
broad
substrate
scope,
various
can
be
obtained
good
yields
with
excellent
enantioselectivity.
Further
elaboration
provides
access
to
diverse
set
valuable
chiral
building
blocks.
Organic Letters,
Год журнала:
2018,
Номер
20(24), С. 8035 - 8038
Опубликована: Дек. 3, 2018
Carreira's
iridium-(P,
olefin)
phosphoramidite-based
catalytic
system
that
allows
asymmetric
allyl–allylboronate
cross-coupling
with
high
enantioselectivity
is
reported.
This
transformation
tolerates
a
large
variety
of
racemic
branched
allylic
alcohols
and
allylboronate
substrates.
The
utility
the
coupling
demonstrated
in
concise
synthesis
(−)-preclamol.
Chemical Science,
Год журнала:
2021,
Номер
12(8), С. 3070 - 3075
Опубликована: Янв. 1, 2021
The
first
iridium-catalyzed
enantioselective
allylic
alkylation
of
an
olefinic
C(sp2)–H
bond
–
that
α,β-unsaturated
carbonyl
compound,
is
developed
in
cooperation
with
Lewis
base
catalysis.
Chemical Science,
Год журнала:
2022,
Номер
13(42), С. 12491 - 12497
Опубликована: Янв. 1, 2022
Hydroxy-directed
iridium-catalyzed
enantioselective
formal
β-C(sp2)-H
allylic
alkylation
of
kojic
acid
and
structurally
related
α,β-unsaturated
carbonyl
compounds
is
developed.
This
reaction,
catalyzed
by
an
Ir(i)/(P,olefin)
complex,
utilizes
the
nucleophilic
character
α-hydroxy
carbonyls,
to
introduce
allyl
group
at
its
β-position
in
a
branched-selective
manner
good
excellent
yield
with
uniformly
high
enantioselectivity
(up
>99.9
:
0.1
er).
To
best
our
knowledge,
this
report
represents
first
example
use
transition
metal
highly
transformation.
Organic Letters,
Год журнала:
2019,
Номер
22(1), С. 249 - 252
Опубликована: Дек. 16, 2019
An
efficient
organocatalytic
enantioselective
synthesis
of
chiral
1,4-benzodioxepines
is
described.
By
proper
incorporation
an
intramolecular
oxetane
desymmetrization
process,
a
range
benzylic
alcohols
bearing
internal
reacted
in
the
presence
suitable
phosphoric
acid
catalyst
to
form
with
high
enantioselectivity.
This
process
provides
new
catalytic
asymmetric
example
direct
seven-membered
heterocycles
good
stereocontrol.
Angewandte Chemie,
Год журнала:
2018,
Номер
130(39), С. 13112 - 13116
Опубликована: Июль 2, 2018
Abstract
We
report
the
successful
generation
of
(diborylmethyl)zinc(II)
species
by
transmetallation
beteween
isolable
(diborylmethyl)lithium
and
zinc(II)
halide
(X=Br,
Cl)
their
application
in
synthesis
enantioenriched
gem
‐diborylalkanes
bearing
a
stereogenic
center
at
β‐position
diboryl
groups
an
asymmetric
allylic
substitution
reaction.
The
reaction
has
broad
substrate
scope,
various
can
be
obtained
good
yields
with
excellent
enantioselectivity.
Further
elaboration
provides
access
to
diverse
set
valuable
chiral
building
blocks.
