Synthesis of isoquinolones by visible-light-induced deaminative [4+2] annulation reactions

Chemical Communications, Год журнала: 2020, Номер 56(39), С. 5259 - 5262

Опубликована: Янв. 1, 2020

Herein a metal-free approach for the synthesis of isoquinolone derivatives by means photoinitiated deaminative [4+2] annulation alkynes and N-amidepyridinium salts is described. This protocol exhibits broad scope good functional group tolerance regioselectivity under benign reaction conditions. Preliminary studies suggest that critical amide radical derived from photocatalytic cleavage N-N bond salt, which adds to triple alkyne undergoes process afford desired isoquinolones.

Язык: Английский

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Cobalt(iii)-catalyzed redox-neutral [4+2]-annulation of N-chlorobenzamides/acrylamides with alkylidenecyclopropanes at room temperature

Chemical Communications, Год журнала: 2021, Номер 57(30), С. 3692 - 3695

Опубликована: Янв. 1, 2021

An efficient synthesis of substituted 3,4-dihydroisoquinolinones through [4+2]-annulation N-chlorobenzamides/acrylamides with alkylidenecyclopropanes using a less expensive and air stable Co(iii) catalyst is demonstrated.

Язык: Английский

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Isoquinolone Syntheses by Annulation Protocols

Catalysts, Год журнала: 2021, Номер 11(5), С. 620 - 620

Опубликована: Май 11, 2021

Isoquinolones (isoquinolin-1(2H)-ones) are one of the important nitrogen-heterocyclic compounds having versatile biological and physiological activities, their synthetic methods have been recently developed greatly. This short review illustrates significant advances in construction isoquinolone ring with atom- step-economy, focusing on intermolecular annulation protocols intramolecular cyclization presence a variety catalyst systems. The syntheses isoquinolone-fused rings also included.

Язык: Английский

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Progress in Transition‐Metal‐Catalyzed Synthesis of Benzo‐Fused Oxygen‐ and Nitrogen Heterocyclic Compounds from Benzoic Acids

Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(2), С. 124 - 141

Опубликована: Янв. 10, 2023

Abstract Transition‐metal‐catalyzed oxidative annulation reactions can be used to synthesize various benzo‐fused oxygen‐ and nitrogen‐containing heterocyclic compounds from benzoic acids. This review deals with publications the past 15 years that focus on modifications of reaction conditions variations coupling reagents this end, as well development methods characterized by sustainability, a broad range substrates, high tolerance functional groups in constructing skeletons are commonly found drugs bioactive molecules. summarizes categorizes mechanisms reagents. magnified image

Язык: Английский

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Redox-neutral C–H annulation strategies for the synthesis of heterocycles via high-valent Cp*Co(iii) catalysis

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(19), С. 3918 - 3941

Опубликована: Янв. 1, 2023

This review demonstrates the redox-neutral synthetic approaches towards valuable heterocycles such as isoquinolines, indoles, isoquinolones, and tetrahydroquinolines via high-valent Cp*Co( iii ) catalysis.

Язык: Английский

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