Organic Letters,
Год журнала:
2020,
Номер
22(5), С. 1807 - 1812
Опубликована: Фев. 17, 2020
A
hindered
β-amino
amide
transient
directing
group
effects
di-trans-arylation
of
cyclohexanecarbaldehydes.
The
N-substituents
are
shown
to
affect
yield
and
can
enhance
the
rate
arylation
compared
with
α-amino
acid.
Addition
a
pyridone
ligand
further
enhanced
reactivity.
reaction
is
successful
for
range
aryl
iodides,
various
substituted
cyclohexane
carboxaldehydes,
providing
functionalized
products
from
simple
feedstocks.
mechanism
proposed
evoking
enamine.
Chemical Reviews,
Год журнала:
2022,
Номер
122(15), С. 12544 - 12747
Опубликована: Июль 17, 2022
1,1,1,3,3,3-Hexafluoroisopropanol
(HFIP)
is
a
polar,
strongly
hydrogen
bond-donating
solvent
that
has
found
numerous
uses
in
organic
synthesis
due
to
its
ability
stabilize
ionic
species,
transfer
protons,
and
engage
range
of
other
intermolecular
interactions.
The
use
this
exponentially
increased
the
past
decade
become
choice
some
areas,
such
as
C–H
functionalization
chemistry.
In
review,
following
brief
history
HFIP
an
overview
physical
properties,
literature
examples
reactions
using
or
additive
are
presented,
emphasizing
effect
each
reaction.
Chemical Science,
Год журнала:
2021,
Номер
12(11), С. 3857 - 3870
Опубликована: Янв. 1, 2021
Among
numerous
solvents
available
for
chemical
transformations,
1,1,1,3,3,3-hexafluoro-2-propanol
(popularly
known
as
HFIP)
has
attracted
enough
attention
of
the
scientific
community
in
recent
years.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(17), С. 7358 - 7426
Опубликована: Янв. 1, 2022
Transition
metal
catalysis
has
contributed
immensely
to
C-C
bond
formation
reactions
over
the
last
few
decades,
and
alkylation
is
no
exception.
The
superiority
of
such
methodologies
traditional
evident
from
minimal
reaction
steps,
shorter
times,
atom
economy
while
also
allowing
control
regio-
stereo-selectivity.
In
particular,
hydrocarbonation
alkenes
grabbed
increased
attention
due
its
fundamental
ability
effectively
selectively
synthesise
a
wide
range
industrially
pharmaceutically
relevant
moieties.
This
review
attempts
provide
scientific
viewpoint
systematic
analysis
recent
developments
in
transition-metal-catalyzed
various
C-H
bonds
using
simple
activated
olefins.
key
features
mechanistic
studies
involved
these
transformations
are
described
briefly.
Organic & Biomolecular Chemistry,
Год журнала:
2018,
Номер
16(25), С. 4582 - 4595
Опубликована: Янв. 1, 2018
C-H
functionalisation
promises
a
paradigm
shift
in
synthetic
planning.
However,
the
additional
steps
often
required
to
install
and
remove
directing
groups
currently
detract
from
efficiency.
The
strategy
of
reversible
installation
group
via
an
imine
linkage
has
recently
emerged,
with
formed
hydrolysed
situ.
Such
transient
can
promote
transition
metal
catalysed
unactivated
bonds
aldehydes,
ketones
amines.
This
approach
removes
usually
for
covalent
use
catalytic
quantities
forming
component.
review
updates
rapidly
developing
field
on
sp2
sp3
carbon
centres,
form
new
C-C
C-X
bonds.
We
focus
structures
as
mono
or
bidentate
coordinating
various
catalysts.
Reaction Chemistry & Engineering,
Год журнала:
2018,
Номер
4(2), С. 244 - 253
Опубликована: Окт. 30, 2018
HFIP
has
developed
immense
importance
in
the
C–H
functionalization
methodology.
Both
reactivity
and
selectivity
have
been
vastly
improved
using
whose
H-bonding
to
substrate
facilitates
accelerates
activation.
This
review
summarizes
chronological
development
of
evolution
activation
along
with
important
mechanistic
details.
Asian Journal of Organic Chemistry,
Год журнала:
2019,
Номер
8(11), С. 1949 - 1969
Опубликована: Март 13, 2019
Abstract
Maleimide
and
succinimide
core
moieties
are
present
in
various
natural
products
pharmaceuticals.
In
addition,
these
derivatives
can
be
readily
modified
into
biologically
important
organic
molecules
including
pyrrolidines
γ‐lactams.
A
transition‐metal‐catalyzed
chelation‐assisted
functionalization
of
inert
C−H
bond
with
electrophiles
or
nucleophiles
is
one
the
efficient
methods
to
construct
chemical
bonds
a
highly
atom‐
step‐economical
manner.
The
review
describes
recent
advances
reaction
involving
maleimides
by
activation
methodology.
having
directing
groups,
such
as
ketone,
acyl,
pyridyl,
pyrimidyl,
oxime,
amide,
imidate,
chromone,
azo,
N
‐sulfonyl
ketimine,
carboxylic
acids,
aldimines,
were
described.
scope,
limitation
mechanistic
investigation
alkylation,
annulation
alkenylation
reactions
discussed
elaborately.
This
article
includes
entire
report
on
bond‐forming
strategy
until
end
2018.
ChemSusChem,
Год журнала:
2019,
Номер
12(13), С. 2955 - 2969
Опубликована: Апрель 8, 2019
Transition
metal-catalyzed
C-H
bond
functionalization
is
among
the
most
efficient
and
powerful
strategies
in
synthetic
organic
chemistry
to
derivatize
otherwise
inert
sites
of
molecules
for
construction
C-C
C-heteroatom
bonds.
However,
additional
steps
are
often
required
install
directing
groups
realize
selective
substrates.
These
tedious
run
counter
step-economical
nature
activation.
In
contrast,
direct
substrate
by
using
transient
ligands
avoids
unnecessary
pre-functionalization
This
Minireview
provides
a
short
overview
major
progress
made
this
field
at
sp2
sp3
carbon
centers
with
different
working
modes,
including
covalent,
hydrogen,
ionic
Chemical Communications,
Год журнала:
2018,
Номер
54(79), С. 11200 - 11203
Опубликована: Янв. 1, 2018
A
Rh(iii)-catalyzed
C–H
activation
of
indole
at
the
C4-position
leading
to
novel
and
switchable
functionalization
has
been
reported
by
employing
a
weakly
co-ordinating
COCF3
group
as
directing
group.
Organic Chemistry Frontiers,
Год журнала:
2020,
Номер
7(12), С. 1527 - 1569
Опубликована: Янв. 1, 2020
Heterocyclic
alkenes
and
their
derivatives
are
an
important
class
of
reactive
feedstock
valuable
synthons.
This
review
highlights
the
transition-metal-catalyzed
coupling
heterocyclic
alkenesviaa
C–H
functionalization
strategy.
