The Journal of Organic Chemistry,
Год журнала:
2019,
Номер
84(18), С. 11417 - 11424
Опубликована: Авг. 16, 2019
A
facile
and
effective
alkoxylation
protocol
of
quinoxalin-2(1H)-ones
with
primary
or
secondary
alcohols
via
cross-dehydrogenative
coupling
under
catalyst-free
conditions
has
been
disclosed.
This
method
provides
a
powerful
convenient
access
to
3-alkoxylquinoxalin-2(1H)-ones
in
good
excellent
yields
by
utilizing
PhI(OTFA)2
as
an
oxidant
allows
easily
obtain
potential
drug
molecules
containing
3-alkoxylquinoxalin-2(1H)-one
skeletons.
Organic & Biomolecular Chemistry,
Год журнала:
2019,
Номер
17(24), С. 5863 - 5881
Опубликована: Янв. 1, 2019
The
direct
C3-functionalization
of
quinoxalin-2(1H)-ones
via
C–H
bond
activation
has
recently
attracted
considerable
attention,
due
to
their
diverse
biological
activities
and
chemical
properties.
Organic Letters,
Год журнала:
2018,
Номер
21(1), С. 325 - 329
Опубликована: Дек. 21, 2018
A
visible-light-initiated
α-perfluoroalkyl-β-heteroarylation
of
various
alkenes
with
perfluoroalkyl
iodides
and
quinoxalin-2(1H)-ones
is
presented.
This
three-component
radical
cascade
reaction
allows
an
efficient
synthesis
a
range
containing
quinoxalin-2(1H)-one
derivatives
in
moderate
to
excellent
yields
under
mild
conditions.
Reactions
proceed
via
acidic
aminyl
radicals
that
are
readily
deprotonated
give
the
corresponding
anions
able
sustain
chain
as
single
electron
transfer
reducing
reagents.
Hence,
overall
classifies
electron-catalyzed
process.
Organic Letters,
Год журнала:
2019,
Номер
21(12), С. 4698 - 4702
Опубликована: Июнь 6, 2019
The
first
example
of
oxidative
C–H
fluoroalkoxylation
quinoxalinones
with
fluoroalkyl
alcohols
under
transition-metal
and
solvent-free
conditions
is
described.
This
approach
provides
the
synthesis
fluoroalkoxylated
quinoxaline
derivatives
good
to
excellent
yields
mild
reactions
conditions.
method
can
also
be
extended
facile
efficient
histamine-4
receptor.
Green Chemistry,
Год журнала:
2020,
Номер
23(1), С. 374 - 378
Опубликована: Окт. 23, 2020
Aryl
radicals
were
generated
for
the
first
time
from
aryl
acyl
peroxides
in
ethyl
acetate
under
ambient
conditions
and
visible-light
illumination
absence
of
any
additive,
metal
catalyst,
or
external
photosensitizer.
Organic Chemistry Frontiers,
Год журнала:
2020,
Номер
7(3), С. 492 - 498
Опубликована: Янв. 1, 2020
Visible-light-mediated
procedure
has
been
developed
for
the
synthesis
of
3-acyl
quinoxalin-2(1H)-ones
through
acridine
red
catalyzed
decarboxylative
acylation
α-oxo-carboxylic
acids
with
quinoxalin-2(1H)-ones.
Green Chemistry,
Год журнала:
2019,
Номер
21(23), С. 6241 - 6245
Опубликована: Янв. 1, 2019
We
have
developed
a
metal-free
and
catalyst-free
visible-light-promoted
direct
C–H
sulfenylation
of
quinoxalin-2(1H)-ones
with
thiols
for
the
synthesis
diverse
3-sulfenylquinoxalin-2(1H)-ones.
Organic Chemistry Frontiers,
Год журнала:
2019,
Номер
6(8), С. 1173 - 1182
Опубликована: Янв. 1, 2019
A
facile
and
efficient
transition-metal-free
decarboxylative
radical
coupling
reaction
of
α,α-difluoroarylacetic
acids
with
quinoxalin-2(1H)-ones
has
been
developed
under
mild
conditions.
Advanced Synthesis & Catalysis,
Год журнала:
2019,
Номер
361(23), С. 5490 - 5498
Опубликована: Сен. 16, 2019
Abstract
An
efficient
approach
using
a
photocatalytic
strategy
for
C−H
perfluoroalkylation
of
quinoxalinones
under
aerobic
oxidation
condition
has
been
developed.
Such
transformation
employs
readily
available
sodium
perfluoroalkanesulfinates
as
reagents
and
demonstrates
good
functional
group
compatibility,
affording
corresponding
products
in
moderate
to
yields.
Compared
with
previous
procedures,
this
protocol
uses
oxygen
oxidant,
avoids
the
use
external
additive.
A
radical
mechanism
is
involved
reaction.
magnified
image
Chemistry - A European Journal,
Год журнала:
2019,
Номер
26(2), С. 369 - 373
Опубликована: Окт. 9, 2019
A
practical
and
scalable
protocol
for
visible-light-accelerated
arylation
alkylation
of
quinoxalin-2(1H)-ones
with
hydrazines
is
reported.
In
this
protocol,
a
hydrazone-based
two-dimensional
covalent
organic
frameworks
(2D-COF-1)
was
employed
as
the
heterogeneous
photocatalyst
(PC).
Due
to
its
excellent
photocatalytic
properties,
good
chemical
stability
nature,
present
method
exhibits
high
efficiency,
functional
group
tolerance,
easy
scalability
remarkable
catalyst
reusability.
More
importantly,
it
provides
an
alternative
way
that
allows
rapid
access
various
C3
arylated
or
alkylated
in
greener
sustainable
manner.
Advanced Synthesis & Catalysis,
Год журнала:
2018,
Номер
361(5), С. 1033 - 1041
Опубликована: Окт. 22, 2018
Abstract
An
efficient
protocol
for
the
synthesis
of
3‐aminoquinoxalinones
via
electrochemical
dehydrogenative
C‐3
amination
quinoxalin‐2(1
H
)‐ones
was
developed.
With
aliphatic
amines
and
azoles
as
nitrogen
sources,
a
series
obtained
in
up
to
99%
yield.
This
direct
electrolytic
method
avoids
use
transition
metals
external
oxidants,
represents
an
appealing
alternative
3‐aminoquinoxalinones.
magnified
image
