The Journal of Organic Chemistry,
Год журнала:
2019,
Номер
84(18), С. 11417 - 11424
Опубликована: Авг. 16, 2019
A
facile
and
effective
alkoxylation
protocol
of
quinoxalin-2(1H)-ones
with
primary
or
secondary
alcohols
via
cross-dehydrogenative
coupling
under
catalyst-free
conditions
has
been
disclosed.
This
method
provides
a
powerful
convenient
access
to
3-alkoxylquinoxalin-2(1H)-ones
in
good
excellent
yields
by
utilizing
PhI(OTFA)2
as
an
oxidant
allows
easily
obtain
potential
drug
molecules
containing
3-alkoxylquinoxalin-2(1H)-one
skeletons.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 11, 2023
Abstract
The
multicomponent
reactions
of
quinoxalin‐2(1
H
)‐ones
has
attracted
considerable
interest
due
to
their
significant
biological
and
chemical
activities.
very
recent
advances
(from
2021
the
beginning
2023)
on
radical
three‐component
cascade
reaction
)‐one
derivatives
at
C3
position
were
summarized
in
this
mini‐review.
According
kind
types
involved,
some
representative
examples
detailed
mechanism
have
been
categorized
discussed.
red
front
was
covered
by
Figure
1.
Advanced Synthesis & Catalysis,
Год журнала:
2019,
Номер
361(7), С. 1662 - 1667
Опубликована: Янв. 25, 2019
Abstract
A
convenient
C−H
amination
of
quinoxalin‐2‐ones
has
been
developed.
This
transformation
provides
concise
access
to
3‐aminoquinoxalin‐2(1
H
)‐ones
with
a
broad
tolerance
functional
groups,
utilizing
TMSN
3
as
an
amino
source
under
simple
and
mild
conditions.
The
target
are
important
intermediates
for
the
synthesis
biologically
active
3‐
N
‐substituted
quinoxalin‐2‐one
derivatives.
magnified
image
Organic Letters,
Год журнала:
2020,
Номер
23(1), С. 195 - 201
Опубликована: Дек. 23, 2020
Herein,
a
novel
method
for
the
gram-scale
synthesis
of
(E)-quinoxalinone
oximes
through
multicomponent
reaction
under
mild
conditions
is
described.
Such
transformation
was
performed
transition-metal-free
conditions,
affording
(E)-oximes
in
moderate-to-good
yield
recrystallization.
Our
methodology
demonstrates
successful
combination
Mannich-type
and
radical
coupling,
providing
green
practical
approach
potentially
bioactive
quinoxalinone-containing
molecules.
Organic Letters,
Год журнала:
2020,
Номер
22(17), С. 6960 - 6965
Опубликована: Авг. 26, 2020
A
feasible
arylaminomethyl
radical-triggered
tandem
annulation
reaction
has
been
developed
toward
a
large
variety
of
poly
fused
heterocycles,
tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones,
by
reacting
diverse
quinoxalin-2(1H)-ones
with
various
N-arylglycines
in
green
solvent
(DMC)
the
presence
CsPbBr3
under
white-light
irradiation
conditions.
The Journal of Organic Chemistry,
Год журнала:
2019,
Номер
84(18), С. 11417 - 11424
Опубликована: Авг. 16, 2019
A
facile
and
effective
alkoxylation
protocol
of
quinoxalin-2(1H)-ones
with
primary
or
secondary
alcohols
via
cross-dehydrogenative
coupling
under
catalyst-free
conditions
has
been
disclosed.
This
method
provides
a
powerful
convenient
access
to
3-alkoxylquinoxalin-2(1H)-ones
in
good
excellent
yields
by
utilizing
PhI(OTFA)2
as
an
oxidant
allows
easily
obtain
potential
drug
molecules
containing
3-alkoxylquinoxalin-2(1H)-one
skeletons.
