Organic & Biomolecular Chemistry,
Год журнала:
2018,
Номер
17(6), С. 1395 - 1401
Опубликована: Дек. 20, 2018
A
newly
developed
Ming-Phos
ligand
with
a
3,5-bis(trifluoromethyl)phenyl
substituent
was
demonstrated
to
be
highly
efficient
for
Ag-catalyzed
asymmetric
[3
+
2]
cycloaddition
reactions
of
azomethine
ylides
maleimides,
cyclopentene-1,3-diones,
and
N-(2-t-butylphenyl)maleimide.
Being
easily
prepared
on
the
gram
scale
in
one
step,
combination
Ag
catalyst
enables
synthesis
variety
functionalized
bicyclic
pyrrolidine
derivatives
good
yields
excellent
enantioselectivities
under
mild
conditions.
Synthesis,
Год журнала:
2020,
Номер
53(06), С. 1046 - 1060
Опубликована: Дек. 21, 2020
Abstract
This
review
summarizes
the
advances
made
on
synthesis
and
functionalization
of
furans
via
gold
catalysis
during
period
between
2016
2020.
A
separate
section
is
dedicated
to
tandem
gold-catalyzed
furans.
1
Introduction
2
Gold-Catalyzed
Synthesis
Furans
2.1
Cycloisomerizations
Alkynyl
Cumulenyl
Alcohols
2.2
Allenyl
Ketones
2.3
Reactions
with
External
Oxidants
2.4
Miscellaneous
3
Functionalization
3.1
Cycloadditions
3.2
Furan
Ring
Decorations
3.3
Involving
Opening
4
Tandem
Furans
4.1
Followed
by
Cycloaddition
4.2
a
Gold
1,3-
or
1,4-Dipole
Intermolecular
Annulation
4.3
Carbene
Trapping
5
Conclusion
Angewandte Chemie,
Год журнала:
2020,
Номер
132(49), С. 22175 - 22180
Опубликована: Сен. 2, 2020
Abstract
A
palladium‐catalyzed
intermolecular
dynamic
kinetic
asymmetric
dearomatization
of
3‐arylindoles
with
internal
alkynes
was
developed
the
use
achiral
Xantphos
and
chiral
sulfinamide
phosphine
ligand
(
PC‐Phos
)
as
co‐ligands.
This
method
could
deliver
various
spiro[indene‐1,3′‐indole]
compounds
in
good
yields
(up
to
95
%
yield)
up
98
ee
.
The
salient
features
transformation
include
readily
available
substrates,
ease
scale‐up
versatile
functionalization
products.
mechanistic
experiments
gave
some
insights
on
active
intermediates.
Angewandte Chemie,
Год журнала:
2019,
Номер
131(33), С. 11566 - 11570
Опубликована: Июнь 14, 2019
Abstract
Reported
herein
is
an
asymmetric
Pd/PC‐Phos‐catalyzed
denitrogenative
cyclization
of
benzotriazoles
with
allenes
and
N‐allenamides,
representing
the
first
example
enantioselective
cyclizations
benzotriazoles.
A
series
optically
active
3‐methyleneindolines
were
obtained
in
good
yields
high
ee
values.
The
use
inexpensive
readily
available
starting
materials,
regio‐
enantioselectivity,
a
broad
substrate
scope,
mild
reaction
conditions,
no
need
for
base,
as
well
versatile
functionalization
make
this
approach
attractive.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(15), С. 3204 - 3226
Опубликована: Авг. 5, 2024
Abstract
Due
to
the
presence
of
multiple
reactive
sites,
including
an
alkyne,
alkene,
and
a
ketone,
2‐(1‐alkynyl)‐2‐alken‐1‐ones
(yne‐enones)
can
successfully
participate
in
synthesis
various
carbo‐,
heterocycles,
as
well
acyclic
compounds.
In
this
regard,
wide
variety
transition
metal
catalysts
organocatalysts
are
utilized
cycloaddition
functionalization
reactions
yne‐enones
with
other
coupling
partners.
Considering
versatility
synthon,
review,
we
have
described
metal‐catalyzed
non‐metal‐catalyzed
transformations
over
last
decade.
Organic & Biomolecular Chemistry,
Год журнала:
2018,
Номер
17(6), С. 1395 - 1401
Опубликована: Дек. 20, 2018
A
newly
developed
Ming-Phos
ligand
with
a
3,5-bis(trifluoromethyl)phenyl
substituent
was
demonstrated
to
be
highly
efficient
for
Ag-catalyzed
asymmetric
[3
+
2]
cycloaddition
reactions
of
azomethine
ylides
maleimides,
cyclopentene-1,3-diones,
and
N-(2-t-butylphenyl)maleimide.
Being
easily
prepared
on
the
gram
scale
in
one
step,
combination
Ag
catalyst
enables
synthesis
variety
functionalized
bicyclic
pyrrolidine
derivatives
good
yields
excellent
enantioselectivities
under
mild
conditions.
