Molecules,
Год журнала:
2024,
Номер
29(11), С. 2485 - 2485
Опубликована: Май 24, 2024
Thioethers
are
critical
in
the
fields
of
pharmaceuticals
and
organic
synthesis,
but
most
methods
for
synthesis
alkyl
thioethers
employ
foul-smelling
thiols
as
starting
materials
or
generate
them
by-products.
Additionally,
air-sensitive
easily
oxidized
to
produce
disulfides
under
atmospheric
conditions;
thus,
a
novel
method
synthesizing
is
necessary.
This
paper
reports
simple,
effective,
green
dialkyl
aryl
thioether
derivatives
using
odorless,
stable,
low-cost
ROCS2K
thiol
surrogate.
transformation
offers
broad
substrate
scope
good
functional
group
tolerance
with
excellent
selectivity.
The
reaction
likely
proceeds
via
xanthate
intermediates,
which
can
be
readily
generated
nucleophilic
substitution
halides
transition-metal-free
base-free
conditions.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(52)
Опубликована: Июнь 28, 2023
Abstract
Selenium,
originally
described
as
a
toxin,
turns
out
to
be
crucial
trace
element
for
life
that
appears
selenocysteine
and
its
dimer,
selenocystine.
From
the
point
of
view
drug
developments,
selenium‐containing
drugs
are
isosteres
sulfur
oxygen
with
advantage
presence
selenium
atom
confers
antioxidant
properties
high
lipophilicity,
which
would
increase
cell
membrane
permeation
leading
better
oral
bioavailability.
In
this
article,
we
have
focused
on
relevant
features
atom,
above
all,
corresponding
synthetic
approaches
access
variety
organoselenium
molecules
along
proposed
reaction
mechanisms.
The
preparation
biological
selenosugars,
including
selenoglycosides,
selenonucleosides,
selenopeptides,
other
compounds
will
treated.
We
attempted
condense
most
important
aspects
interesting
examples
chemistry
into
single
article.
Chemical Communications,
Год журнала:
2024,
Номер
60(9), С. 1152 - 1155
Опубликована: Янв. 1, 2024
An
efficient
approach
for
the
selective
construction
of
C2,3-
or
C2,5-aminochalcogenated
indole
derivatives
has
been
developed,
which
enables
oxidative
regioselective
aminochalcogenation
indolines
with
amines
and
dichalconides.
Chemical Communications,
Год журнала:
2024,
Номер
60(34), С. 4613 - 4616
Опубликована: Янв. 1, 2024
We
report
an
innovative
synthetic
strategy
for
the
generation
of
polysubstituted
indoles
from
indolines,
aryldiazonium
salts,
and
azoles.
The
methodology
encompasses
electrophilic
substitution
reaction
affording
C5-indoline
intermediates
which
undergo
iodine-mediated
oxidative
transformation
coupled
with
C-H
functionalization
to
yield
indole
derivatives.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(11), С. 1714 - 1755
Опубликована: Апрель 12, 2023
Abstract
In
the
last
decade,
free
radicals
have
found
a
wide
application
in
functionalization
of
unsaturated
compounds,
such
as
alkenes,
alkynes,
and
arenes,
via
free‐radical
addition
to
carbon‐carbon
π‐bonds.
these
processes,
intermolecular
attack
on
aromatic
substrates
represents
challenge
due
relatively
high
resistance
π‐system
reactions
comparison
alkene
C=C
bonds.
The
heterocycles
is
especially
interesting
diversity
their
structures
chemical
properties
well
importance
for
medicinal
chemistry,
agrochemistry,
materials
science.
Addition
C‐centered
widely
known
Minisci‐type
well‐reviewed.
this
paper,
we
summarized
main
achievements
less
explored
group
processes:
by
heteroatom‐centered
(O‐,
N‐,
S‐/Se‐,
P‐radicals)
with
emphasis
papers
published
after
2010.
Literature
analysis
revealed
strong
trend
towards
usage
electrochemistry
photoredox‐catalysis
generation
recent
years.
remaining
fundamental
problem
field
lack
experimental
support
proposed
mechanisms
frequent
existence
several
plausible
reaction
pathways.
progress
mechanistic
studies
can
significantly
improve
prediction
optimal
conditions
depending
structure.
ACS Catalysis,
Год журнала:
2019,
Номер
9(12), С. 11438 - 11446
Опубликована: Ноя. 5, 2019
Simultaneous
formation
of
C–C/C–N
bonds
provides
insight
into
the
bottom-up
synthesis
N-heterocycles.
This
work
reports
Ni0/Niδ+
synergistic
catalysis
on
surface
Ni
nanoparticles
for
highly
efficient
one-pot
bonds,
affording
1,2,3,4-tetrahydroquinoline
and
its
derivatives
from
2-amino
benzyl
alcohol
ethanol
without
any
addition
liquor
base
or
external
hydrogen.
has
been
achieved
by
regulating
particle
size
activating
with
O2.
In
dehydrogenation
−CH2–OH
to
−CH═O,
C══C
C═N
via
concurrent
cross-condensation,
transformation
C═C/C═N
hydrogen
transfer,
found
be
rate-determining
step.
Reducing
effectively
increases
number
Niδ+
sites,
which
accelerates
catalytic
through
between
Ni0
sites.
The
sites
can
further
increased
appropriately
Chemical Communications,
Год журнала:
2020,
Номер
56(18), С. 2807 - 2810
Опубликована: Янв. 1, 2020
Unprecedented
direct
access
to
novel
2-diarylaminoindolo[2,3-b]indoles
via
aerobic
copper-catalyzed
[3+2]
annulation
of
diarylamines
and
indoles
is
demonstrated.
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
85(17), С. 11104 - 11115
Опубликована: Июль 29, 2020
Remote
C-H
functionalization
at
C5
is
the
most
sparingly
observed
selectivity
in
of
indole
templates.
Herein,
we
reported
that
combination
a
AgSbF6
catalyst
and
phenyliodine
diacetate
oxidation
enabled
selenylation
position
scaffolds
selective
version,
thus
leading
to
formation
wide
scope
5-selenylated
derivatives,
which
are
otherwise
difficult
prepare.
Mechanistic
studies
indicated
current
transformation
follows
radical
process,
tethered
C3
pivaloyl
group
on
plays
roles
both
blocking
active
manipulating
electronic
affinity
arenes.
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
85(8), С. 5629 - 5637
Опубликована: Март 23, 2020
Herein,
a
new
iodide-mediated
three-component
annulation
reaction
of
secondary
anilines,
cyclohexanones,
and
elemental
sulfur
is
demonstrated,
which
allows
access
to
various
phenothiazines
with
the
merits
formation
multiple
chemical
bonds
in
one
single
operation,
high
step
atom
efficiency,
readily
available
feedstocks
catalyst
system,
good
substrate
functional
group
compatibility.
The
developed
chemistry
capable
constructing
novel
structural
diversity
offers
significant
basis
for
further
applications.
Organic Chemistry Frontiers,
Год журнала:
2021,
Номер
8(24), С. 6937 - 6949
Опубликована: Янв. 1, 2021
A
site-specific
C6–H
chalcogenation
of
quinoxalin-2(1
H
)-ones
with
various
diselenides
and
dithiols
is
presented
by
employing
Selectfluor
reagent
as
an
oxidant.
