Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors DOI Open Access
Jian Zhang, Ying Chen, Quannan Wang

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2022, Номер 42(10), С. 3051 - 3051

Опубликована: Янв. 1, 2022

Chiral heterocyclic compounds are an important class of chiral substances, which widespread in many drugs, pesticides and catalysts.Therefore, the efficient asymmetric synthesis these becomes a research hotspot organic synthesis.Transition metal-catalyzed cyclization with heteroatom-dipole precursors is method to construct frameworks.Among them, designed based on transition allyl or propargyl substitutions have been extensively studied past two decades occupied role this field.The cyclizations introduced detail.The advantages existing problems current methods analyzed, would provide useful reference for researchers related fields.

Язык: Английский

Synthesis of 3-spirooxindole 3H-indoles through Rh(iii)-catalyzed [4 + 1] redox-neutral spirocyclization of N-aryl amidines with diazo oxindoles DOI

Qianting Zhou,

Xia Song,

Xinying Zhang

и другие.

Organic Chemistry Frontiers, Год журнала: 2021, Номер 8(15), С. 4131 - 4137

Опубликована: Янв. 1, 2021

Presented herein is a novel synthesis of 3-spirooxindole 3H-indoles via the coupling and spirocyclization N-aryl amidines with diazo oxindoles.

Язык: Английский

Процитировано

35
Axially chiral styrene-based organocatalysts and their application in asymmetric cascade Michael/cyclization reaction DOI Creative Commons
Hao Yu,

Zi-Hao Li,

Zhi‐Gang Ma

и другие.

Chemical Science, Год журнала: 2023, Номер 14(35), С. 9496 - 9502

Опубликована: Янв. 1, 2023

An axially chiral styrene-based organocatalyst, featuring a combination of structure and pyrrole ring, has been designed synthesized. This catalyst demonstrates remarkable capabilities in producing wide range densely substituted spirooxindoles that feature an alkyne-substituted quaternary stereogenic center. These are generated through mild cascade Michael/cyclization reactions, resulting high conversion rates exceptional enantioselectivity. Our catalytic model, based on experiments, X-ray analysis DFT calculations suggests matched π-π interactions multiple H-bonds between the organocatalyst substrates play significant roles controlling stereoselectivity reaction.

Язык: Английский

Процитировано

14
Palladium-catalyzed ring-opening [5+2] annulation of vinylethylene carbonates (VECs) and C5-substituted Meldrum's acids: rapid synthesis of 7-membered lactones DOI

Fei Li,

Xin Chen,

Ben‐Qing Huang

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(13), С. 1774 - 1777

Опубликована: Янв. 1, 2024

A novel approach for the synthesis of unsaturated 7-membered lactones by Pd-catalyzed [5+2] dipolar cycloaddition vinylethylene carbonates (VECs) and C5-substituted Meldrum's acid derivatives has been developed.

Язык: Английский

Процитировано

5
Palladium-catalyzed enantioselective [5 + 4] annulation of ortho-quinone methides and vinylethylene carbonates DOI
Chao Xia, Dong‐Chao Wang,

Gui‐Rong Qu

и другие.

Organic Chemistry Frontiers, Год журнала: 2020, Номер 7(12), С. 1474 - 1480

Опубликована: Янв. 1, 2020

Highly enantioselective [5 + 4] annulations of ortho-quinone methides with vinylethylene carbonates are enabled by asymmetric palladium catalysis for the synthesis chiral nine-membered benzo-heterocycles.

Язык: Английский

Процитировано

35
Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors DOI Open Access
Jian Zhang, Ying Chen, Quannan Wang

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2022, Номер 42(10), С. 3051 - 3051

Опубликована: Янв. 1, 2022

Chiral heterocyclic compounds are an important class of chiral substances, which widespread in many drugs, pesticides and catalysts.Therefore, the efficient asymmetric synthesis these becomes a research hotspot organic synthesis.Transition metal-catalyzed cyclization with heteroatom-dipole precursors is method to construct frameworks.Among them, designed based on transition allyl or propargyl substitutions have been extensively studied past two decades occupied role this field.The cyclizations introduced detail.The advantages existing problems current methods analyzed, would provide useful reference for researchers related fields.

Язык: Английский

Процитировано

22