Polycyclic aromatic compounds,
Год журнала:
2022,
Номер
43(5), С. 4103 - 4110
Опубликована: Июнь 14, 2022
A
clean
and
simple
methodology
was
developed
for
the
synthesis
of
substituted
indazoles
using
heteropoly
acids
containing
tungsten,
molybdenum
metal
catalyzed
condensation
reaction
between
2-hydroxy
benzaldehydes/acetophenones
hydrazine
hydrate/phenyl
hydrazine.
The
conditions
are
optimized
two
different
such
as
H3PMo12O40
H3PW12O40
conventional
ultrasound
sonication
method.
Yield
products
improved
to
92
95%
acid
catalyst
which
is
reusable,
cost
effective
easy
handle.
Chemistry - A European Journal,
Год журнала:
2020,
Номер
26(72), С. 17289 - 17317
Опубликована: Май 29, 2020
Abstract
Sulfur‐containing
scaffold,
as
a
ubiquitous
structural
motif,
has
been
frequently
used
in
natural
products,
bioactive
chemicals
and
pharmaceuticals,
particularly
C−S/N−S
bonds
are
indispensable
many
biological
important
compounds
pharmaceuticals.
Development
of
mild
general
methods
for
formation
great
significance
modern
research.
Iodine
its
derivatives
have
recognized
inexpensive,
environmentally
benign
easy‐handled
catalysts
or
reagents
to
promote
the
construction
under
reaction
conditions,
with
good
regioselectivities
broad
substrate
scope.
Especially
based
on
this,
several
new
strategies,
such
oxidation
relay
strategy,
greatly
developed
accelerated
advancement
this
field.
This
review
focuses
recent
advances
iodine
promoted
hybridized
formation.
The
features
mechanisms
corresponding
reactions
summarized
results
some
cases
compared
those
previous
reports.
In
addition,
future
domain
is
discussed.
Organic Letters,
Год журнала:
2019,
Номер
22(1), С. 140 - 144
Опубликована: Дек. 20, 2019
We
report
an
I2/FeCl3-co-promoted
formal
[2
+
2+1]
annulation
of
aryl
methyl
ketones,
2-aminobenzyl
alcohols,
and
p-toluenesulfonylmethyl
isocyanide
(TosMIC)
by
neighboring
group
(-CH2OH)
assistance.
This
is
a
novel
example
using
the
Van
Leusen
reagent
as
unique
C1N1
"two-atom
synthon"
in
synthesis
imidazoles.
Preliminary
mechanism
studies
showed
that
TsCH2NH2
might
be
key
intermediate
this
reaction.
Furthermore,
reaction
not
only
unlocks
strategy
for
imidazole
synthesis,
but
also
exploits
new
reactivity
TosMIC.
New Journal of Chemistry,
Год журнала:
2021,
Номер
45(36), С. 16389 - 16425
Опубликована: Янв. 1, 2021
Molecular
iodine
contributes
significantly
to
organic
transformations
in
synthetic
chemistry.
It
works
effectively
due
its
mild
Lewis
acidic
character,
ability
as
an
oxidizing
agent,
good
moisture
stability,
and
easy
availability.
Organic Letters,
Год журнала:
2021,
Номер
23(22), С. 8910 - 8915
Опубликована: Ноя. 10, 2021
Chemical
transformation
with
vinylene
carbonate
as
an
emerging
synthetic
unit
has
recently
attracted
considerable
attention.
This
report
is
a
novel
conversion
pattern
carbonate,
in
which
such
vibrant
reagent
unprecedentedly
acts
difunctional
coupling
partner
to
complete
the
C-H
annulation
of
free
anilines.
From
commercially
available
substrates,
this
protocol
leads
rapid
construction
synthetically
versatile
2-methylquinoline
derivatives
(43
examples)
excellent
functionality
tolerance.
Asian Journal of Organic Chemistry,
Год журнала:
2022,
Номер
12(1)
Опубликована: Ноя. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2142 - 2164
Опубликована: Янв. 17, 2024
Abstract
N‐Heterocyclic
compounds,
in
particular,
quinolines
and
quinazolines
are
frequently
used
medicinal
chemistry.
Therefore,
the
direct
clean
synthesis
of
these
valuable
scaffolds
has
been
a
great
interest
for
many
years.
2‐Aminobenzyl
alcohols
as
an
alternative
reactant
instead
unstable
expensive
2‐aminobenzaldehydes
can
be
construction
N‐fused
heterocycles
including
quinolines,
quinazolines,
oxazines,
thiazines,
selenazines,
imidazoles,
diazepines,
etc.
In
this
review
article,
we
have
discussed
recent
developments
use
2‐aminobenzyl
diverse
heterocycles.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(12), С. 8381 - 8388
Опубликована: Июнь 9, 2021
A
novel
I2-mediated
Povarov
reaction
of
arylacetylenes
and
anilines
for
the
synthesis
2,4-substituted
quinolines
has
been
developed,
in
which
arylacetylene
first
acts
as
both
a
diene
precursor
dienophile.
This
work
further
develops
to
expand
types
precursors.
Preliminary
mechanistic
studies
indicate
that
I2/DMSO
system
realized
oxidative
carbonylation
C(sp)–H
then
undergoes
[4
+
2]
cycloaddition
reaction.
