The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(15), С. 9994 - 10005
Опубликована: Июль 13, 2021
Herein,
unprecedented
manganese-catalyzed
direct
α-alkenylation
of
amides
using
alcohols
is
reported.
Aryl
are
reacted
with
diverse
primary
alcohols,
which
provided
the
α,β-unsaturated
in
moderate
to
good
yields
excellent
selectivity.
Mechanistic
studies
indicate
that
Mn(I)
catalyst
oxidizes
their
corresponding
aldehydes
and
also
plays
an
important
role
efficient
C═C
bond
formation
through
aldol
condensation.
This
selective
olefination
facilitated
by
metal–ligand
cooperation
aromatization–dearomatization
process
operating
catalytic
system.
Biorenewable
used
as
alkenylation
reagents
for
challenging
highly
abundant
base
metal
manganese
a
catalyst,
results
water
dihydrogen
only
byproduct,
making
this
transformation
attractive,
sustainable,
environmentally
benign.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(9), С. 4607 - 4647
Опубликована: Янв. 1, 2024
This
review
collectively
discussed
the
utilisation
of
alcohols
in
various
organic
transformations
and
their
application
toward
intermediates
drugs,
drug
derivatives
natural
product-like
molecules.
Organic Letters,
Год журнала:
2020,
Номер
22(3), С. 837 - 841
Опубликована: Янв. 9, 2020
An
efficient
cobalt-catalyzed
migrational
isomerization
of
styrenes
was
developed
using
the
thiazoline
iminopyridine
(TIP)
ligand.
This
reaction
is
operationally
simple
and
atom-economical
readily
available
starting
materials
to
access
trisubstituted
alkenes.
Even
when
a
0.1
mol
%
catalyst
loading,
could
be
conducted
in
neat
completed
1
h
with
excellent
conversion
high
E
stereoselectivity.
Catalysis Science & Technology,
Год журнала:
2022,
Номер
12(18), С. 5695 - 5702
Опубликована: Янв. 1, 2022
The
synthesis
of
N-heterocycles
has
been
considered
an
emerging
area
chemical
research
due
to
their
extensive
utilization
in
pharmaceuticals,
materials
science,
and
natural
product
synthesis.
Organic Letters,
Год журнала:
2020,
Номер
22(16), С. 6458 - 6463
Опубликована: Авг. 12, 2020
Herein,
an
efficient
and
selective
nickel-catalyzed
dehydrogenation
of
five-
six-membered
N-heterocycles
is
presented.
The
transformation
occurs
in
the
presence
alkyl,
alkoxy,
chloro,
free
hydroxyl
primary
amine,
internal
terminal
olefin,
trifluoromethyl,
ester
functional
groups.
Synthesis
important
ligand
antimalarial
drug
quinine
demonstrated.
Mechanistic
studies
revealed
that
cyclic
imine
serves
as
key
intermediate
for
this
stepwise
transformation.
European Journal of Organic Chemistry,
Год журнала:
2020,
Номер
2020(15), С. 2155 - 2179
Опубликована: Март 18, 2020
Quinolines
and
their
derivatives
have
always
been
promising
leads
for
drug
discovery,
material
applications
designing
new
catalysts.
In
the
past
decade,
C(sp
3
)‐H
functionalization
of
2‐methyl
azaarenes,
particularly
quinolines,
has
become
one
highly
facile
synthetic
routes
generation
chemical
libraries
quinolines.
this
minireview,
we
showcase
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