Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

ACS Omega, Год журнала: 2024, Номер 9(31), С. 33303 - 33334

Опубликована: Июль 25, 2024

The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe agents. unique magnetic tunable properties iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including Though IONPs act as nonspecific agent, their activities are directly or indirectly linked with synthesis methods, synthesizing precursors, size, shapes, concentration, surface modifications. Alteration these parameters could accelerate decelerate production reactive oxygen species (ROS). An increase in ROS role disrupts bacterial cell walls, membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), affects metabolic processes Krebs cycle, fatty acid synthesis, ATP glycolysis, mitophagy). In this review, we will investigate antibacterial activity bare surface-modified influence physiochemical on activity. Additionally, report potential mechanism IONPs' action driving

Язык: Английский

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MOF/COF heterostructure hybrid composite-based molecularly imprinted photoelectrochemical sensing platform for determination of dibutyl phthalate: A further expansion for MOF/COF application

Biosensors and Bioelectronics, Год журнала: 2022, Номер 223, С. 115017 - 115017

Опубликована: Дек. 14, 2022

Язык: Английский

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A novel Nb2C MXene based aptasensor for rapid and sensitive multi-mode detection of AFB1

Biosensors and Bioelectronics, Год журнала: 2023, Номер 242, С. 115725 - 115725

Опубликована: Окт. 6, 2023

Язык: Английский

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High-density Au nanoshells assembled onto Fe3O4 nanoclusters for integrated enrichment and photothermal/colorimetric dual-mode detection of SARS-CoV-2 nucleocapsid protein

Biosensors and Bioelectronics, Год журнала: 2023, Номер 241, С. 115688 - 115688

Опубликована: Сен. 10, 2023

Язык: Английский

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Hollow SnO2/CdS QDs/CdCO3 heterostructured nanocubes coupled with hollow PtPd/MnCo–CeO2 nanozyme-mediated synergistic amplification for ultrasensitive PEC immunoanalysis of lung cancer biomarker

Biosensors and Bioelectronics, Год журнала: 2023, Номер 235, С. 115398 - 115398

Опубликована: Май 15, 2023

Язык: Английский

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Highly efficient carbon supported Co–Ir nanozyme for the determination of total antioxidant capacity in foods

Biosensors and Bioelectronics, Год журнала: 2023, Номер 236, С. 115416 - 115416

Опубликована: Май 24, 2023

Язык: Английский

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A review on functionalization and potential application spectrum of magnetic nanoparticles (MNPs) based systems

Chemistry of Inorganic Materials, Год журнала: 2024, Номер 2, С. 100035 - 100035

Опубликована: Янв. 9, 2024

Magnetic nanoparticles (MNPs) owing to its broad application spectrum are gaining popularity in recent years. The current review article offers a one-stop-reference for young scientists as it encompasses the literature reports on method of synthesis and functionalization MNPs based system their potential applications diverse fields. This summarizes details about different methods reported MNPs, need immobilization active species onto surface functionalized carrying out biologically important organic transformation. Applications not only restricted field catalysis but also showed sectors. Over last few decades, there has been increasing global concern over public health issues due contamination water bodies with harmful dyes toxic metals. Monitoring subsequent removal these metals from contaminated is one major environmental remediation interests today. In this context, absorbents have shown exuberant remove deleterious pollutants high efficiency, low cost, faster kinetics, easy accessibility design flexibility. Besides, proved enzyme pharmaceutical industries. being class nanoscale materials revolutionizing clinical diagnostic therapeutic techniques currently employed next generation drug carriers. Furthermore, NP-Based Biosensors was detection presence SARS-CoV-2, ribonucleic acid (RNA) virus responsible nearly 6.1 million deaths occurred COVID-19 pandemic. fuel industry used production biodiesel which emerges promising alternative fossil derived energy sources because eco-friendly, clean biodegradable nature. short, we provided in-depth synthesis,

Язык: Английский

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Selective inhibitory activity of multidrug-resistant bacteria by zinc oxide nanoparticles

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(1), С. 111870 - 111870

Опубликована: Янв. 4, 2024

Язык: Английский

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Mechanistic Study of Cancer Drug Delivery: Current Techniques, Limitations, and Future Prospects

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117535 - 117535

Опубликована: Март 20, 2025

Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.

Язык: Английский

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Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(7), С. 3563 - 3572

Опубликована: Июль 1, 2022

Coronavirus disease (COVID-19) is an infectious that has posed a global health challenge caused by the SARS-CoV-2 virus. Early management and diagnosis of are crucial for timely treatment, traceability, reduction viral spread. We have developed rapid method using Graphene-based Field-Effect Transistor (Gr-FET) ultrasensitive detection Spike S1 antigen (S1-Ag). The in-house antispike antibody (S1-Ab) was covalently immobilized on surface carboxy functionalized graphene channel carbodiimide chemistry. Ultraviolet-visible spectroscopy, Fourier-Transform Infrared Spectroscopy, X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM), Optical Microscopy, Raman Scanning Electron (SEM), Enzyme-Linked Immunosorbent Assays (ELISA), device stability studies were conducted to characterize bioconjugation fabrication process Gr-FET. In addition, electrical response evaluated monitoring change in resistance Ag-Ab interaction real time. For S1-Ag, our Gr-FET devices tested range 1 fM μM with limit 10 standard buffer. fabricated highly sensitive, specific, capable detecting low levels S1-Ag.

Язык: Английский

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