Journal of Infertility and Reproductive Biology,
Год журнала:
2024,
Номер
12(4), С. 31 - 44
Опубликована: Дек. 20, 2024
Male
infertility
affects
a
significant
portion
of
the
global
population,
contributing
to
nearly
half
all
cases.
Common
underlying
causes
include
disruptions
in
spermatogenesis,
hormonal
imbalances,
and
genetic
anomalies.
Traditional
treatments,
such
as
hormone
therapy,
surgical
interventions,
assisted
reproductive
technologies,
often
exhibit
limited
efficacy
due
their
invasive
nature,
systemic
side
effects,
high
financial
costs.
This
study
explores
nanomedicine’s
potential
targeted
approach
address
these
limitations,
particularly
through
advanced
nanoparticle-based
drug
delivery
systems
aimed
at
enhancing
sperm
function
improving
fertility
outcomes.
Various
types
nanoparticles,
including
liposomes,
polymer-based
metal
are
assessed
for
abilities
deliver
therapeutic
agents
directly
spermatogenic
cells
support
testes.
By
modulating
critical
cellular
pathways
necessary
production
survival,
nanoparticles
offer
enhanced
effects
with
minimized
exposure.
Additionally,
highlights
nanoparticle
applications
personalized
medicine,
allowing
tailored
treatment
approaches
based
on
individual
profiles.
Although
further
clinical
trials
needed
confirm
safety,
therapies
promising
path
forward
minimally
invasive,
male
infertility.
Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100041 - 100041
Опубликована: Июль 9, 2024
Artificial
Intelligence
(AI)
and
Nanotechnology
are
two
cutting-edge
fields
that
hold
immense
promise
for
revolutionizing
various
aspects
of
science,
technology,
everyday
life.
This
review
delves
into
the
intersection
these
disciplines,
highlighting
synergistic
relationship
between
AI
Nanotechnology.
It
explores
how
techniques
such
as
machine
learning,
deep
neural
networks
being
employed
to
enhance
efficiency,
precision,
scalability
nanotechnology
applications.
Furthermore,
it
discusses
challenges,
opportunities,
future
prospects
integrating
with
nanotechnology,
paving
way
transformative
advancements
in
diverse
domains
ranging
from
healthcare
materials
science
environmental
sustainability
beyond.
Molecules,
Год журнала:
2025,
Номер
30(4), С. 884 - 884
Опубликована: Фев. 14, 2025
Researchers
have
extensively
investigated
photosensitizer
(PS)
derivatives
for
various
applications
due
to
their
superior
photophysical
and
electrochemical
properties.
However,
inherent
problems,
such
as
instability
self-quenching
under
physiological
conditions,
limit
biological
applications.
Metal-organic
frameworks
(MOFs)
covalent
organic
(COFs)
represent
two
relatively
new
material
types.
These
materials
high
surface
areas
permanent
porosity,
they
show
a
tremendous
deal
of
potential
like
these.
This
review
summarizes
key
synthesis
processes
highlights
recent
advancements
in
integrating
PS-based
COF
MOF
nanocarriers
biomedical
while
addressing
obstacles
prospects.
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(1), С. 325 - 336
Опубликована: Янв. 16, 2025
Nanoparticles
have
become
a
transforming
platform
in
drug
delivery
systems.
Their
remarkable
advancement
over
traditional
methods
builds
upon
an
improvement
bioavailability,
stability,
and
controlled
of
therapeutic
agents.
Here,
we
discuss
the
broad
spectrum
potential
nanoparticle-based
Challenges,
innovations,
surface
modification
strategies
that
affect
their
clinical
translation
are
discussed.
Notwithstanding
they
present,
challenges
including
biocompatibility,
toxicity,
targeting
efficiency
persist
restricting
extensive
utilization.
The
review
emphasizes
recent
advancements,
stimuli-responsive
nanoparticles,
which
provide
release
reaction
to
environmental
triggers,
as
well
targeted
delivery,
facilitates
selective
accumulation
agents
at
designated
sites
disease.
Besides,
techniques,
such
PEGylation,
ligand
conjugation,
charge
modulation,
been
highly
promising
improving
stability
reducing
immunogenicity,
enhancing
cellular
uptake.
future
systems
based
on
nanoparticles
will
address
these
through
new
innovations
nanoparticle
design
effect
more
effective
treatments.
While
research
advances,
likely
bring
revolution
personalized
medicine,
tailoring
medical
therapy
for
different
diseases
with
minimal
side
effects
better
patient
outcomes.
Chemical Research in Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Nanoparticles,
defined
by
their
nanoscale
dimensions
and
unique
physicochemical
properties,
are
widely
utilized
in
healthcare,
electronics,
environmental
sciences,
consumer
products.
However,
increasing
evidence
of
potential
embryotoxic
effects
during
pregnancy
underscores
the
need
for
a
molecular-level
understanding
interactions
embryonic
development.
Nanoparticles
such
as
titanium
dioxide,
silver,
cerium
oxide,
copper
quantum
dots
can
cross
placental
barrier
interfere
with
crucial
developmental
processes.
At
molecular
level,
they
disrupt
signaling
pathways
like
Wnt
Hedgehog,
induce
oxidative
stress
inflammation,
cause
genotoxic
effects,
all
critical
sensitive
phases,
organogenesis.
Furthermore,
these
nanoparticles
interact
directly
cellular
components,
including
DNA,
proteins,
lipids,
impairing
function
viability.
Innovative
strategies
to
mitigate
nanoparticle
toxicity,
surface
modifications
incorporation
biocompatible
coatings,
discussed
solutions
reduce
adverse
interactions.
Various
laboratory
animal
models
used
investigate
nanoparticle-induced
embryotoxicity
evaluated
efficacy
limitations,
providing
insights
into
applicability
effects.
This
Account
examines
mechanisms
which
compromise
development
emphasizes
importance
designing
safer
minimize
maternal-fetal
exposure
risks,
particularly
biomedical
applications.
Erciyes Üniversitesi Veteriner Fakültesi Dergisi,
Год журнала:
2025,
Номер
22(1), С. 13 - 18
Опубликована: Апрель 18, 2025
In
recent
years,
nanotechnology
has
emerged
as
a
rapidly
advancing
field
with
diverse
applications
across
various
sectors
including
materials
science,
electronics,
healthcare,
aerospace,
environmental
sustainability,
defense,
biotechnology,
agriculture,
and
food
industries.
Mesoporous
silica
nanoparticles
(MSNs)
have
recently
gained
significance
nanomaterials
due
to
their
stability,
inert
properties,
thermal
durability,
low
density,
minimal
toxicity,
biocompatibility.
These
attributes
will
make
mesoporous
instrumental
in
drug
delivery
systems,
cellular
imaging,
therapeutic
interventions.
this
study,
aimed
at
assessing
the
potential
of
MSNs
effective
carriers
for
spermatozoa
(sptz),
experimental
groups
were
established
control
(C),
MSN10
(10
μg/107
sptz),
MSN20
(20
MSN40
(40
sptz).
To
investigate
hypothesis,
semen
was
collected
from
five
healthy
rams
(2-3
years
age),
pooled,
diluted,
divided
into
groups.
Following
analyses
conducted
on
motility,
dead-live
ratio,
functional
integrity
sperm's
plasma
membrane
(HOST),
abnormal
ratios
replicates.
It
observed
that
did
not
negative
effect
freezability
ram
terms
ratio
HOST
data,
but
caused
an
increase
motility
(MSN40)
head
tail
abnormality
levels
compared
group,
though
still
within
acceptable
ranges.
light
data
obtained,
it
is
suggested
can
be
used
biocarriers
basic
spermatological
parameters,
necessary
expand
scope
research
conduct
more
detailed
analyzes.
