Journal of Infertility and Reproductive Biology,
Год журнала:
2024,
Номер
12(4), С. 31 - 44
Опубликована: Дек. 20, 2024
Male
infertility
affects
a
significant
portion
of
the
global
population,
contributing
to
nearly
half
all
cases.
Common
underlying
causes
include
disruptions
in
spermatogenesis,
hormonal
imbalances,
and
genetic
anomalies.
Traditional
treatments,
such
as
hormone
therapy,
surgical
interventions,
assisted
reproductive
technologies,
often
exhibit
limited
efficacy
due
their
invasive
nature,
systemic
side
effects,
high
financial
costs.
This
study
explores
nanomedicine’s
potential
targeted
approach
address
these
limitations,
particularly
through
advanced
nanoparticle-based
drug
delivery
systems
aimed
at
enhancing
sperm
function
improving
fertility
outcomes.
Various
types
nanoparticles,
including
liposomes,
polymer-based
metal
are
assessed
for
abilities
deliver
therapeutic
agents
directly
spermatogenic
cells
support
testes.
By
modulating
critical
cellular
pathways
necessary
production
survival,
nanoparticles
offer
enhanced
effects
with
minimized
exposure.
Additionally,
highlights
nanoparticle
applications
personalized
medicine,
allowing
tailored
treatment
approaches
based
on
individual
profiles.
Although
further
clinical
trials
needed
confirm
safety,
therapies
promising
path
forward
minimally
invasive,
male
infertility.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 8, 2024
Abstract
Thrombotic
cardiovascular
diseases
are
a
prevalent
factor
contributing
to
both
physical
impairment
and
mortality.
Thrombolysis
ischemic
mitigation
have
emerged
as
leading
contemporary
therapeutic
approaches
for
addressing
the
consequences
of
injury
reperfusion
damage.
Herein,
an
innovative
cellular-cloaked
spermatozoon-driven
microcellular
submarine
(SPCS),
comprised
multimodal
motifs,
was
designed
integrate
nano-assembly
thrombolytics
with
immunomodulatory
ability
derived
from
innate
magnetic
hyperthermia.
Rheotaxis-based
navigation
utilized
home
cross
clot
barrier,
finally
accumulate
in
vascular
organs,
where
thrombolytic
motif
“switched-on”
by
action
thrombus
red
blood
cell-driven
In
murine
model,
SPCS
system
combining
hyperthermia
demonstrated
capacity
augment
delivery
efficacy,
produce
nanotherapeutic
outcomes,
exhibit
potent
activity,
ameliorate
tissue
These
findings
underscore
multifaceted
potential
our
approach,
offering
ischemia-mitigating
effects.
Given
its
extended
effects
thrombus-targeting
capability,
this
biocompatible
holds
promise
agent
enhancing
efficacy
preventing
risks
after
managing
thrombosis.
Graphical
abstract
Journal of Infertility and Reproductive Biology,
Год журнала:
2024,
Номер
12(4), С. 31 - 44
Опубликована: Дек. 20, 2024
Male
infertility
affects
a
significant
portion
of
the
global
population,
contributing
to
nearly
half
all
cases.
Common
underlying
causes
include
disruptions
in
spermatogenesis,
hormonal
imbalances,
and
genetic
anomalies.
Traditional
treatments,
such
as
hormone
therapy,
surgical
interventions,
assisted
reproductive
technologies,
often
exhibit
limited
efficacy
due
their
invasive
nature,
systemic
side
effects,
high
financial
costs.
This
study
explores
nanomedicine’s
potential
targeted
approach
address
these
limitations,
particularly
through
advanced
nanoparticle-based
drug
delivery
systems
aimed
at
enhancing
sperm
function
improving
fertility
outcomes.
Various
types
nanoparticles,
including
liposomes,
polymer-based
metal
are
assessed
for
abilities
deliver
therapeutic
agents
directly
spermatogenic
cells
support
testes.
By
modulating
critical
cellular
pathways
necessary
production
survival,
nanoparticles
offer
enhanced
effects
with
minimized
exposure.
Additionally,
highlights
nanoparticle
applications
personalized
medicine,
allowing
tailored
treatment
approaches
based
on
individual
profiles.
Although
further
clinical
trials
needed
confirm
safety,
therapies
promising
path
forward
minimally
invasive,
male
infertility.
