Engineering an Extracellular Matrix Mimic Using Hemoglobin Protein Nanofibrils DOI
Qun Chen,

Kai Steinmetz,

Jin Kyo Oh

и другие.

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(9), С. 6089 - 6100

Опубликована: Авг. 26, 2024

Extracellular matrix (ECM) is essential for tissue development, providing structural support and a microenvironment that necessary cells. As engineering advances, there growing demand ECM mimics. Polycaprolactone (PCL) commonly used synthetic polymer mimic materials. However, its biologically inactive surface limits direct application in engineering. Our study aimed to improve the biocompatibility of PCL by incorporating hemoglobin nanofibrils (HbFs) into using an electrospinning technique. HbFs were formed from bovine (Hb) extracted industrial byproducts designed offer improved cell adhesion property. The fabricated HbFs@PCL electrospun scaffold exhibits fibroblast adherence, proliferation, deeper infiltration compared with pure scaffold, indicating potential be mimic. This represents pioneering utilization Hb-sourced scaffolds applications.

Язык: Английский

Green synthesis of highly luminous lemon juice-based carbon dots for antimicrobial assessment and fingerprint detection DOI
Arshad Hussain Wazir, Qudrat Ullah Khan, Faizan Ullah

и другие.

International Journal of Materials Research (formerly Zeitschrift fuer Metallkunde), Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract Carbon dots are regarded as a brand new class of nanostructures in the carbonaceous family that have piqued curiosity researchers wide range bio applications. This work focuses on synthesis and characterization carbon dots, well their latent fingerprint detection antibacterial/antifungal capabilities. Highly luminous were prepared by optimizing simple hydrothermal carbonization settings at 180 °C for 12 h using lemon juice raw precursor. The resulting product was examined Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray analysis, diffractometery, ultraviolet–visible spectrophotometer. as-prepared found to be extremely bright when excited under ultraviolet light ( λ = 365 nm). presence oxygen functionalities surface revealed spectrocopy. diffraction pattern confirmed amorphous structure with an average size 7 nm determined Scherrer equation. morphology analysis exhibited aggregated form irregular spherical shapes. chemical examination validated elemental makeup juice-based dots. fingerprints yielded positive results. In addition, obtained displayed antifungal antibacterial activity against tested pathogenic fungal bacterial strains.

Язык: Английский

Процитировано

0

Effect of precursors on carbon dot functionalization and applications: a review DOI
Sara Strickland,

Luke Fourroux,

Dimitri Pappas

и другие.

The Analyst, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Carbon dots (CDs) are a type of carbon-based nanoparticle (NP) that have risen in popularity due to their unique tuneable physicochemical and optical properties.

Язык: Английский

Процитировано

0

Spermidine Carbon Quantum Dotsas an Alternative Antimicrobial Agent for Hatcheries Rearing Pacific White Shrimp (Litopenaeus Vannamei) DOI
Hung‐Yun Lin, Han-Tso Lin,

Yun-Ru Chiang

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Diagnostic and therapeutic strategies in combating implanted medical device-associated bacterial biofilm infections DOI
Ayush Amod, Ananya Anurag Anand, Amaresh Kumar Sahoo

и другие.

Folia Microbiologica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

0

Liquid crystalline coatings loaded with colistin for preventing development of biofilms on orthopedic implants DOI Creative Commons
Şeref Akay,

Manija Nazim,

Roudabeh Foroughian

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

The current antibacterial strategies focus on antibiotic therapy and extensive hygienic measures during orthopedic surgery. However, potential development of implant-associated infections remains a persistent clinical challenge. There is, therefore, growing interest in introducing innovative safe for preventing combating biofilm implants. Antibacterial coatings, particularly, are attractive local delivery agents. We aim this proof-of-concept study at novel translatable implant coating approach, focusing directed assembly inverse non-lamellar lyotropic liquid crystalline (LLC) nanostructures implants prevention initial bacterial attachment formation through the widely used cationic colistin (COL). On exposure dry lipid films deposited model to aqueous solutions COL prepared different concentrations, set LLC coatings based commercial distilled monoglyceride product (or glycerol monooleate) were produced. In addition small-angle X-ray scattering (SAXS) characterization investigations, vitro studies conducted evaluating antibiofilm properties against Gram-negative bacteria Pseudomonas aeruginosa. SAXS analysis indicated that all samples bicontinuous cubic Pn3m phases. Significant COL's activity efficient protection adhesion demonstrated with surface produced by using containing concentrations 50 500 µg/mL. serum, detected structural alterations changes also discussed. This highlights implications self-assemblies designing nanostructural implants, which can prevent

Язык: Английский

Процитировано

0

Advanced biomaterials for targeting mature biofilms in periodontitis therapy DOI
Jie Tao,

Yirong Sun,

Guoliang Wang

и другие.

Bioactive Materials, Год журнала: 2025, Номер 48, С. 474 - 492

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0

Screening of Lithium Substituted Ag-TiO2 Nanoparticle Coating for Antibiofilm Application DOI

Lipi Pradhan,

Sobhan Hazra, Sumit Manna

и другие.

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(9), С. 6101 - 6113

Опубликована: Авг. 9, 2024

Bacterial infections and biofilm growth are common mishaps associated with medical devices, they contribute significantly to ill health mortality. Removal of bacterial deposition from these devices is a major challenge, resulting in an immediate necessity for developing antibacterial coatings on the surfaces implants. In this context, we developed innovative coating strategy that can operate at low temperatures (80 °C) preserve devices' integrity functionality. An Ag-TiO

Язык: Английский

Процитировано

1

Engineering an Extracellular Matrix Mimic Using Hemoglobin Protein Nanofibrils DOI
Qun Chen,

Kai Steinmetz,

Jin Kyo Oh

и другие.

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(9), С. 6089 - 6100

Опубликована: Авг. 26, 2024

Extracellular matrix (ECM) is essential for tissue development, providing structural support and a microenvironment that necessary cells. As engineering advances, there growing demand ECM mimics. Polycaprolactone (PCL) commonly used synthetic polymer mimic materials. However, its biologically inactive surface limits direct application in engineering. Our study aimed to improve the biocompatibility of PCL by incorporating hemoglobin nanofibrils (HbFs) into using an electrospinning technique. HbFs were formed from bovine (Hb) extracted industrial byproducts designed offer improved cell adhesion property. The fabricated HbFs@PCL electrospun scaffold exhibits fibroblast adherence, proliferation, deeper infiltration compared with pure scaffold, indicating potential be mimic. This represents pioneering utilization Hb-sourced scaffolds applications.

Язык: Английский

Процитировано

0